PROSPECÇÃO CIENTÍFICA: BIOMOLÉCULAS OBTIDAS DE ALGAS MARINHAS E SUAS POTENCIAIS PERSPECTIVAS PARA O TRATAMENTO DO HIV-1.
Viviane Lima Silva
Resumo
Introdução: Tratando-se do HIV-1, vírus pertencente à família Retroviridae do gênero Lentivírus, a transferência desse vírus para o meio intracelular da célula-alvo, se dá, devido à presença de receptores denominados de CD4 e também por co-receptores conhecidos por CCR5 e CXCR4, presentes nas jangadas lipídicas das células-alvo, os quais as proteínas de fusão do vírus possuem predileção. O objetivo desse estudo é investigar o uso de compostos naturais derivados de algas marinhas como uma alternativa promissora na terapia do HIV-1, pois alguns desses compostos detêm o poder de inibir a ligação entre gp120 e CD4 o que impede a entrada do vírus na célula-alvo. Material e Métodos: Para a construção do presente artigo foi feita uma prospecção científica por meio das bases de dados PubMed, Web of Science e Science Direct, na qual foi inserido o seguinte termo de busca “HIV-1 AND Sargassum”, tanto em inglês como também na língua portuguesa. Discussão: Os únicos achados foram os trabalhos desenvolvidos por Lindwasser e Resh (2002) apontando o ácido mirístico extraído de Sargassum fusiforme como um potente inibidor do HIV-1, já a aplicação do ácido palmítico como forma inibitória para essa imunossupressão foram desenvolvidos por Paskaleva et al. (2009). Resultados: De acordo com a análise nas bases de dados os únicos compostos naturais presentes em algas marinhas que inibiram o HIV-1 foram as da espécie Sargassum fusiforme. Conclusão: Em relação ao uso de bioativos derivados de algas marinhas, as pesquisas ainda são escassas.
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Referências
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Submetido em:
06/01/2021
Revisado em:
12/02/2021
Aceito em:
18/02/2021
Publicado em:
22/02/2021