Brazilian Journal of Anesthesiology
https://app.periodikos.com.br/journal/rba/article/doi/10.1590/S0034-70942010000300012
Brazilian Journal of Anesthesiology
Review Article

Lidocaína por via venosa intraoperatória

Intraoperative intravenous lidocaine

Caio Marcio Barros de Oliveira; Adriana Machado Issy; Rioko Kimiko Sakata

Downloads: 1
Views: 1128

Resumo

JUSTIFICATIVA E OBJETIVOS: Grande parte dos pacientes submetidos à operação experimentam dor moderada a intensa, havendo necessidade de melhorar a técnica analgésica. A lidocaína tem sido usada amplamente por via venosa para tratamento de dor crônica. O objetivo foi fazer uma revisão sobre o uso de lidocaína por via venosa para analgesia pós-operatória. CONTEÚDO: Foi realizada revisão dos aspectos farmacológicos da lidocaína, dos mecanismos de ação desse anestésico local e de estudos clínicos nos quais os autores empregaram lidocaína intraoperatória. CONCLUSÕES: A lidocaína venosa pode promover efeito analgésico para procedimentos cirúrgicos, sendo mais uma alternativa para o tratamento da dor aguda. A realização de mais estudos controlados com diferentes intervenções operatórias poderá trazer mais informações sobre essa modalidade analgésica.

Palavras-chave

ANESTÉSICOS, ANESTÉSICOS, ANESTÉSICOS

Abstract

BACKGROUND AND OBJECTIVES: Most patients undergoing surgery experience moderate to severe pain, indicating the need to improve the anesthetic technique. Intravenous lidocaine has been widely used in the treatment of chronic pain. The objective of this report was to review the use of intravenous lidocaine for postoperative analgesia. CONTENTS: The pharmacologic aspects and mechanism of action of lidocaine as well as clinical studies in which the authors used intraoperative lidocaine were reviewed. CONCLUSIONS: Intravenous lidocaine can promote analgesia in surgical procedures, representing another alternative for the treatment of acute pain. Controlled studies with different surgical interventions could bring more information on this modality of analgesia.

Keywords

ANESTHETICS, ANESTHETICS, PAIN

References

Kehlet H, Holte K. Effect of postoperative analgesia on surgical outcome. Br J Anaesth. 2001;87:62-72.

Kehlet H, Wilmore DW. Multimodal strategies to improve surgical outcome. Am J Surg. 2002;183:630-641.

Beilin B, Shavit Y, Trabekin E. The effects of postoperative pain management on immune response to surgery. Anesth Analg. 2003;97:822-827.

Gottschalk A, Raja SN. Severing the link between acute and chronic pain: the anesthesiologist's role in preventive medicine. Anesthesiology. 2004;101:1063-1065.

Pavlin DJ, Chen C, Penaloza DA. Pain as a factor complicating recovery and discharge after ambulatory surgery. Anesth Analg. 2002;95:627-634.

Apfelbaum JL, Chen C, Mehta SS. Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg. 2003;97:534-540.

Woolf CJ, Decosterd I. Implications of recent advances in the understanding of pain pathophysiology for the assessment of pain in patients. Pain. 1999:S141-147.

Lin E, Calvano SE, Lowry SF. Inflammatory cytokines and cell response in surgery. Surgery. 2000;127:117-126.

Beilin B, Bessler H, Mayburd E. Effects of preemptive analgesia on pain and cytokine production in the postoperative period. Anesthesiolog. 2003;98:151-155.

Guirao X, Lowry SF. Biologic control of injury and inflammation: much more than too little or too late. World J Surg. 1996;20:437-446.

Kato M, Suzuki H, Murakami M. Elevated plasma levels of interleukin-6, interleukin-8 and granulocyte colony- stimulating factor during and after major abdominal surgery. J Clin Anesth. 1997;9:293-298.

Gebhard F, Pfetsch H, Steinbach G. Is interleukin 6 an early marker of injury severity following major trauma in humans?. Arch Surg. 2000;135:291-295.

Hong JY, Lim KT. Effect of preemptive epidural analgesia on cytokine response and postoperative pain in laparoscopic radical hysterectomy for cervical cancer. Reg Anesth Pain Med. 2008;33:44-51.

Kuo CP, Jao SW, Chen KM. Comparison of the effects of thoracic epidural analgesia and i. v infusion with lidocaine on cytokine response, postoperative pain and bowel function in patients undergoing colonic surgery. Br J Anaesth. 2006;97:640-646.

Hollmann MW, Durieux ME. Local anesthetics and the inflammatory response: a new therapeutic indication?. Anesthesiology. 2000;93:858-875.

Okada S, Hagan JB, Kato M. Lidocaine and its analogues inhibit IL-5-mediated survival and activation of human eosinophils. J Immunol. 1998;160:4010-4017.

Taniguchi T, Shibata K, Yamamoto K. Effects of lidocaine administration on hemodynamics and cytokine responses to endotoxemia in rabbits. Crit Care Med. 2000;28:755-759.

Lahav M, Levite M, Bassani L. Lidocaine inhibits secretion of IL-8 and IL-1β and stimulates secretion of IL-1 receptor antagonist by epithelial cells. Clin Exp Immunol. 2002;127:226-233.

de Klaver MJM, Buckingham MG, Rich GF. Lidocaine attenuates cytokine-induced cell injury in endothelial and vascular smooth muscle cells. Anesth Analg. 2003;97:465-470.

Becker DE, Reed KL. Essentials of local anesthetic pharmacology. Anesth Prog. 2006;53:98-109.

Heavner JE. Local anesthetics. Curr Opin Anaesthesiol. 2007;20:336-342.

Catterall WA, Mackie K. Local Anesthetics. Goodman and Gilman's the Pharmacological Basis of Therapeutics. 2006:369-385.

Sheets MF, Hanck DA. Molecular action of lidocaine on the voltage sensors of sodium channels. J Gen Physiol. 2003;121:163-175.

McLure HA, Rubin AP. Review of local anaesthetic agents. Minerva Anestesiol. 2005;71:59-74.

Kindler CH, Yost CS. Two-pore domain potassium channels: new sites of local anesthetic action and toxicity. Reg Anesth Pain Med. 2005;30:260-274.

DeToledo JC. Lidocaine and seizures. Therap Drug Monit. 2000;22:320-322.

Mather LE, Copeland SE, Ladd LA. Acute toxicity of local anesthetics: underlying pharmacokinetic and pharmacodynamic concepts. Reg Anesth Pain Med. 2005;30:553-566.

Rowbotham MC. Treatment of Neuropathic Pain: Perspective on Current Options. International Association for the Study of Pain: Pain 2005 - An Updated Review: Refresher Course Syllabus. 2005:107-119.

Finnerup NB, Biering-Sorensen F, Johannesen IL. Intravenous lidocaine relieves spinal cord injury pain: a andomized controlled trial. Anesthesiology. 2005;102:1023-1030.

Ness TJ. Intravenous lidocaine inhibits visceral nociceptive reflexes and spinal neurons in the rat. Anesthesiology. 2000;92:1685-1691.

Koppert W, Ostermeier N, Sittl R. Low-dose lidocaine reduces secondary hyperalgesia by a central mode of action. Pain. 2000;85:217-224.

Abram SE, Yaksh TL. Systemic lidocaine blocks nerve injury-induced hyperalgesia and nociceptor-driven spinal sensitization in the rat. Anesthesiology. 1994;80:383-391.

Attal N, Rouaud J, Brasseur L. Systemic lidocaine in pain due to peripheral nerve injury and predictors of response. Neurology. 2004;62:218-225.

Attal N, Gaude V, Brasseurn L. Intravenous lidocaine in central pain: a double-blind, placebo- controlled, psychophysical study. Neurology. 2000;54:564-574.

Kalso E. Pharmacological Management of Pain: Anticonvulsants, Antidepressants, and Adjuvants Analgesics. International Association for the Study of Pain: Pain 2005 - An Updated Review: Refresher Course Syllabus. 2005:19-29.

Dirks J, Fabricius P, Petersen KL. The effect of systemic lidocaine on pain and secondary hyperalgesia associated with the heat/capsaicin sensitization model in healthy volunteers. Anesth Analg. 2000;91:967-972.

Mattsson U, Cassuto J, Tarnow P. Intravenous lidocaine infusion in the treatment of experimental human skin burns: digital color image analysis of erythema development. Burns. 2000;26:710-715.

Kawamata M, Takahashi T, Kozuka Y. Experimental incisioninduced pain in human skin: effects of systemic lidocaine on flare formation and hyperalgesia. Pain. 2002;100:77-89.

Koppert W, Weigand M, Neumann F. Perioperative intravenous lidocaine has preventive effects on postoperative pain and morphine consumption after major abdominal surgery. Anesth Analg. 2004;98:1050-1055.

Wu CT, Borel CO, Lee MS. The interaction effect of perioperative cotreatment with dextromethorphan and intravenous lidocaine on pain relief and recovery of bowel function after laparoscopic cholecystectomy. Anesth Analg. 2005;100:448-453.

Kaba A, Laurent SR, Detroz BJ. Intravenous lidocaine infusion facilitates acute rehabilitation after laparoscopic colectomy. Anesthesiology. 2007;106:11-18.

Herroeder S, Pecher S, Schönherr ME. Systemic lidocaine shortens length of hospital stay after colorectal surgery: a double-blinded, randomized, placebo-controlled trial. Ann Surg. 2007;246:192-200.

McCleane G. Intravenous lidocaine: an outdated or underutilized treatment for pain?. J Palliat Med. 2007;10:798-805.

Omote K. Intravenous lidocaine to treat postoperative pain management: novel strategy with a long-established drug. Anesthesiology. 2007;106:5-6.

Amir R, Argoff CE, Bennett GJ. The role of sodium channels in chronic inflammatory and neuropathic pain. J Pain. 2006;7(5^s3):S1-S29.

Araujo MC, Sinnott CJ, Strichartz GR. Multiple phases of relief from experimental mechanical allodynia by systemic lidocaine: responses to early and late infusions. Pain. 2003;103:21-29.

Hahnenkamp K, Durieux ME, Hahnenkamp A. Local anaesthetics inhibit signaling of human NMDA receptors recombinantly expressed in Xenopus laevis oocytes: role of protein kinase C. Br J Anaesth. 2006;96:77-87.

Yanagidate E, Strichartz GR. Local anesthetics. Handb Exp Pharmacol. 2007:95-127.

Petrenko AB, Yamakura T, Baba H. The role of N-methy-lD-aspartate (NMDA) receptors in pain: a review. Anesth Analg. 2003;97:1108-1116.

Hollmann MW, Difazio CA, Durieux ME. Ca-signaling G-protein-coupled receptors: a new site of local anesthetic action?. Reg Anesth Pain Med. 2001;26:565-571.

Watkins LR, Maier SF. Beyond neurons: evidence that immune and glial cells contribute to pathological pain states. Physiol Rev. 2002;82:981-1011.

Martin F, Cherif K, Gentili ME. Lack of impact of intravenous lidocaine on analgesia, functional recovery, and nociceptive pain threshold after total hip arthroplasty. Anesthesiology. 2008;109:118-123.

5dd2de040e8825220fc63493 rba Articles
Links & Downloads

Braz J Anesthesiol

Share this page
Page Sections