Kehlet H, Holte K. Effect of postoperative analgesia on surgical outcome. Br J Anaesth. 2001;87:62-72.

Kehlet H, Wilmore DW. Multimodal strategies to improve surgical outcome. Am J Surg. 2002;183:630-641.

Beilin B, Shavit Y, Trabekin E. The effects of postoperative pain management on immune response to surgery. Anesth Analg. 2003;97:822-827.

Gottschalk A, Raja SN. Severing the link between acute and chronic pain: the anesthesiologist's role in preventive medicine. Anesthesiology. 2004;101:1063-1065.

Pavlin DJ, Chen C, Penaloza DA. Pain as a factor complicating recovery and discharge after ambulatory surgery. Anesth Analg. 2002;95:627-634.

Apfelbaum JL, Chen C, Mehta SS. Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg. 2003;97:534-540.

Woolf CJ, Decosterd I. Implications of recent advances in the understanding of pain pathophysiology for the assessment of pain in patients. Pain. 1999:S141-147.

Lin E, Calvano SE, Lowry SF. Inflammatory cytokines and cell response in surgery. Surgery. 2000;127:117-126.

Beilin B, Bessler H, Mayburd E. Effects of preemptive analgesia on pain and cytokine production in the postoperative period. Anesthesiolog. 2003;98:151-155.

Guirao X, Lowry SF. Biologic control of injury and inflammation: much more than too little or too late. World J Surg. 1996;20:437-446.

Kato M, Suzuki H, Murakami M. Elevated plasma levels of interleukin-6, interleukin-8 and granulocyte colony- stimulating factor during and after major abdominal surgery. J Clin Anesth. 1997;9:293-298.

Gebhard F, Pfetsch H, Steinbach G. Is interleukin 6 an early marker of injury severity following major trauma in humans?. Arch Surg. 2000;135:291-295.

Hong JY, Lim KT. Effect of preemptive epidural analgesia on cytokine response and postoperative pain in laparoscopic radical hysterectomy for cervical cancer. Reg Anesth Pain Med. 2008;33:44-51.

Kuo CP, Jao SW, Chen KM. Comparison of the effects of thoracic epidural analgesia and i. v infusion with lidocaine on cytokine response, postoperative pain and bowel function in patients undergoing colonic surgery. Br J Anaesth. 2006;97:640-646.

Hollmann MW, Durieux ME. Local anesthetics and the inflammatory response: a new therapeutic indication?. Anesthesiology. 2000;93:858-875.

Okada S, Hagan JB, Kato M. Lidocaine and its analogues inhibit IL-5-mediated survival and activation of human eosinophils. J Immunol. 1998;160:4010-4017.

Taniguchi T, Shibata K, Yamamoto K. Effects of lidocaine administration on hemodynamics and cytokine responses to endotoxemia in rabbits. Crit Care Med. 2000;28:755-759.

Lahav M, Levite M, Bassani L. Lidocaine inhibits secretion of IL-8 and IL-1β and stimulates secretion of IL-1 receptor antagonist by epithelial cells. Clin Exp Immunol. 2002;127:226-233.

de Klaver MJM, Buckingham MG, Rich GF. Lidocaine attenuates cytokine-induced cell injury in endothelial and vascular smooth muscle cells. Anesth Analg. 2003;97:465-470.

Becker DE, Reed KL. Essentials of local anesthetic pharmacology. Anesth Prog. 2006;53:98-109.

Heavner JE. Local anesthetics. Curr Opin Anaesthesiol. 2007;20:336-342.

Catterall WA, Mackie K. Local Anesthetics. Goodman and Gilman's the Pharmacological Basis of Therapeutics. 2006:369-385.

Sheets MF, Hanck DA. Molecular action of lidocaine on the voltage sensors of sodium channels. J Gen Physiol. 2003;121:163-175.

McLure HA, Rubin AP. Review of local anaesthetic agents. Minerva Anestesiol. 2005;71:59-74.

Kindler CH, Yost CS. Two-pore domain potassium channels: new sites of local anesthetic action and toxicity. Reg Anesth Pain Med. 2005;30:260-274.

DeToledo JC. Lidocaine and seizures. Therap Drug Monit. 2000;22:320-322.

Mather LE, Copeland SE, Ladd LA. Acute toxicity of local anesthetics: underlying pharmacokinetic and pharmacodynamic concepts. Reg Anesth Pain Med. 2005;30:553-566.

Rowbotham MC. Treatment of Neuropathic Pain: Perspective on Current Options. International Association for the Study of Pain: Pain 2005 - An Updated Review: Refresher Course Syllabus. 2005:107-119.

Finnerup NB, Biering-Sorensen F, Johannesen IL. Intravenous lidocaine relieves spinal cord injury pain: a andomized controlled trial. Anesthesiology. 2005;102:1023-1030.

Ness TJ. Intravenous lidocaine inhibits visceral nociceptive reflexes and spinal neurons in the rat. Anesthesiology. 2000;92:1685-1691.

Koppert W, Ostermeier N, Sittl R. Low-dose lidocaine reduces secondary hyperalgesia by a central mode of action. Pain. 2000;85:217-224.

Abram SE, Yaksh TL. Systemic lidocaine blocks nerve injury-induced hyperalgesia and nociceptor-driven spinal sensitization in the rat. Anesthesiology. 1994;80:383-391.

Attal N, Rouaud J, Brasseur L. Systemic lidocaine in pain due to peripheral nerve injury and predictors of response. Neurology. 2004;62:218-225.

Attal N, Gaude V, Brasseurn L. Intravenous lidocaine in central pain: a double-blind, placebo- controlled, psychophysical study. Neurology. 2000;54:564-574.

Kalso E. Pharmacological Management of Pain: Anticonvulsants, Antidepressants, and Adjuvants Analgesics. International Association for the Study of Pain: Pain 2005 - An Updated Review: Refresher Course Syllabus. 2005:19-29.

Dirks J, Fabricius P, Petersen KL. The effect of systemic lidocaine on pain and secondary hyperalgesia associated with the heat/capsaicin sensitization model in healthy volunteers. Anesth Analg. 2000;91:967-972.

Mattsson U, Cassuto J, Tarnow P. Intravenous lidocaine infusion in the treatment of experimental human skin burns: digital color image analysis of erythema development. Burns. 2000;26:710-715.

Kawamata M, Takahashi T, Kozuka Y. Experimental incisioninduced pain in human skin: effects of systemic lidocaine on flare formation and hyperalgesia. Pain. 2002;100:77-89.

Koppert W, Weigand M, Neumann F. Perioperative intravenous lidocaine has preventive effects on postoperative pain and morphine consumption after major abdominal surgery. Anesth Analg. 2004;98:1050-1055.

Wu CT, Borel CO, Lee MS. The interaction effect of perioperative cotreatment with dextromethorphan and intravenous lidocaine on pain relief and recovery of bowel function after laparoscopic cholecystectomy. Anesth Analg. 2005;100:448-453.

Kaba A, Laurent SR, Detroz BJ. Intravenous lidocaine infusion facilitates acute rehabilitation after laparoscopic colectomy. Anesthesiology. 2007;106:11-18.

Herroeder S, Pecher S, Schönherr ME. Systemic lidocaine shortens length of hospital stay after colorectal surgery: a double-blinded, randomized, placebo-controlled trial. Ann Surg. 2007;246:192-200.

McCleane G. Intravenous lidocaine: an outdated or underutilized treatment for pain?. J Palliat Med. 2007;10:798-805.

Omote K. Intravenous lidocaine to treat postoperative pain management: novel strategy with a long-established drug. Anesthesiology. 2007;106:5-6.

Amir R, Argoff CE, Bennett GJ. The role of sodium channels in chronic inflammatory and neuropathic pain. J Pain. 2006;7(5^s3):S1-S29.

Araujo MC, Sinnott CJ, Strichartz GR. Multiple phases of relief from experimental mechanical allodynia by systemic lidocaine: responses to early and late infusions. Pain. 2003;103:21-29.

Hahnenkamp K, Durieux ME, Hahnenkamp A. Local anaesthetics inhibit signaling of human NMDA receptors recombinantly expressed in Xenopus laevis oocytes: role of protein kinase C. Br J Anaesth. 2006;96:77-87.

Yanagidate E, Strichartz GR. Local anesthetics. Handb Exp Pharmacol. 2007:95-127.

Petrenko AB, Yamakura T, Baba H. The role of N-methy-lD-aspartate (NMDA) receptors in pain: a review. Anesth Analg. 2003;97:1108-1116.

Hollmann MW, Difazio CA, Durieux ME. Ca-signaling G-protein-coupled receptors: a new site of local anesthetic action?. Reg Anesth Pain Med. 2001;26:565-571.

Watkins LR, Maier SF. Beyond neurons: evidence that immune and glial cells contribute to pathological pain states. Physiol Rev. 2002;82:981-1011.

Martin F, Cherif K, Gentili ME. Lack of impact of intravenous lidocaine on analgesia, functional recovery, and nociceptive pain threshold after total hip arthroplasty. Anesthesiology. 2008;109:118-123.