Serum uric acid as an adjunct in the assessment of psychiatric disorders: an overview
Jagannadha R. Peela, Abdalla M. Jarari, Harshvaradhan Polamarasetty, Vaishnavi Kanisetti, Krishna Srivathsav Tadikonda, Anuradha Argi, Avinash K. Rawal
http://dx.doi.org/10.5281/zenodo.6780474
Mediterr J Pharm Pharm Sci, vol.2, n2, 6, 2022
Abstract
Oxidative stress is due to altered levels of prooxidants and anti-oxidants in the body. This can lead to tissue damage especially, the central nervous system. Oxidative damage has been implicated in several disorders including some psychiatric disorders such as schizophrenia and major depressive disorder. Uric acid is an anti-oxidant that prevents tissue damage caused by oxidative stress. In this review, the reduced levels of serum uric acid in schizophrenia and depression are discussed. The effect of treatment in these disorders leading to increased serum uric acid levels is also reviewed.
Keywords
Major depressive disorder, oxidative stress, schizophrenia, uric acid
References
- Bošković M, Vovk T, Kores Plesničar B, Grabnar I (2011) Oxidative stress in schizophrenia. Current Neuro-pharmacology. 9 (2): 301-312. doi: 10.2174/157015911795596595
- Bitanihirwe BKY, Woo TU (2011) Oxidative stress in schizophrenia: an integrated approach. Neurosciences and Biobehavioral Reviews. 35 (3): 878-893. doi: 10.1016/j.neubiorev.2010.10.008
- Yao JK, Reddy RD, van Kammen DP (2001) Oxidative damage and schizophrenia: an overview of the evidence and its therapeutic implications. CNS Drugs. 15: 287-310. doi: 10.2165/00023210-200115040-00004
- Chaudhari K, Khanzode S, Khanzode S, Dakhale G, Saoji A, Sarode S (2010) Clinical correlation of alteration of endogenous antioxidant-uric acid level in major depressive disorder. Indian Journal of Clinical Biochemistry. 25 (1): 77-81. doi: 10.1007/s12291-010-0016-z
- Kim TS, Pae CU, Yoon SJ, Jang WY, Lee NJ, Kim JJ, Lee SJ, Lee C, Paik IH, Lee CU (2006) Decreased plasma antioxidants in patients with Alzheimer's disease. International Journal of Geriatric Psychiatry. 21 (4): 344-348. doi. 10.1002/gps.1469
- Yao JK, Reddy R, van Kammen DP (1998) Reduced level of plasma antioxidant uric acid in schizophrenia. Psychiatry Research. 80 (1): 29-39. doi: 10.1016/s0165-1781(98)00051-1
- He Q, You Y, Yu L, Yao L, Lu H, Zhou X, Wu S, Chen L, Chen Y, Zhao X (2020) Uric acid levels in subjects with schizophrenia: A systematic review and meta-analysis. Psychiatry Research. 292: 113305. doi: 10.1016/j. psychres.2020.113305
- Dănău A, Dumitrescu L, Lefter A, Popescu BO (2022) Serum uric acid levels in Parkinson’s disease: a cross-sectional electronic medical record database study from a Tertiary Referral Centre in Romania. Medicina. 58 (2): 245. doi: 10.3390/medicina58020245
- Black CN, Bot M, Scheffer PG, Penninx BWJH (2016) Antioxidant uric acid is lower in current major depression and anxiety disorders. 24th European Congress of Psychiatry. 33S: S114-S289. doi. 10.1016/ j.eurpsy .2016.01.536
- Bartoli F, Trotta G, Crocamo C, Malerba MR, Clerici M, Carrà G (2018) Antioxidant uric acid in treated and untreated subjects with major depressive disorder: a meta-analysis and meta-regression. European Archives of Psychiatry and Clinical Neurosciences. 268 (2): 119-127. doi: 10.1007/s00406-017-0817-7
- Black CN, Bot M, Scheffer PG, Snieder H, Penninx BWJH (2018) Uric acid in major depressive and anxiety disorders. Journal of Affective Disorders. 225: 684-690. doi: 10.1016/j.jad.2017.09.003
- Pae CU, Paik IH, Lee C, Lee SJ, Kim JJ, Lee CU (2004) Decreased plasma antioxidants in schizophrenia. Neuropsychobiology. 50 (1): 54-56. doi: 10.1159/000077942
- Cabungcal JH, Preissmann D, Delseth C, Cuénod M, Do KQ, Schenk F (2007) Transitory glutathione deficit during brain development induces cognitive impairment in juvenile and adult rats: relevance to schizophrenia. Neurobiology of Disease. 26 (3): 634-645. doi: 10.1016/j.nbd.2007.03.001
- Steullet P, Cabungcal JH, Kulak A, Kraftsik, R, Chen Y, Dalton TP, Cuenod M, Do KQ (2010) Redox dysregulation affects the ventral but not dorsal hippocampus: impairment of parvalbumin neurons, gamma oscillations, and related behaviours. The Journal of Neuroscience. 30 (7): 2547-2558. doi: 10.1523/JNEUROS CI.3857-09.2010
- Gonzalez-Liencres C, Tas C, Brown EC, Soner E, Ece O, Zeynep C, Omer A, Aysen ED, Martin B (2014) Oxidative stress in schizophrenia: a case-control study on the effects on social cognition and neurocognition. BMC Psychiatry. 14: 268. doi: 10.1186/s12888-014-0268-x
- Huang D, Liu S (2017) Oxidative stress and schizophrenia. Journal of Psychiatry and Brain Science. 2 (2): 4. doi: 10.20900/jpbs.20170006
- Reddy R, Keshavan M, Yao JK (2003) Reduced plasma antioxidants in first-episode patients with schizo-phrenia. Schizophrenia Research. 62 (3): 205-212. doi: 10.1016/s0920-9964(02)00407-3
- Dadheech G, Sharma P, Gautam S (2012) Oxidative stress-induced response of some endogenous antioxidants in schizophrenia. Indian Journal of Clinical Biochemistry. 27 (3): 278-283. doi: 10.1007/s12291-012-0193-z
- Flatow J, Buckley P, Miller BJ (2013) Meta-analysis of oxidative stress in schizophrenia. Biological Psychiatry. 74 (6): 400-409. doi: 10.1016/j.biopsych.2013.03.018
- Yao JK, Keshavan MS (2011) Antioxidants, redox signaling, and pathophysiology in schizophrenia: an integr-ative view. Antioxidants & Redox Signaling. 15 (7): 2011-2035. doi: 10.1089/ars.2010.3603
- Wu JQ, Kosten TR, Zhang XY (2013) Free radicals, antioxidant defense systems, and schizophrenia. Progress in Neuropsychopharmacology and Biological Psychiatry. 46 (1): 200-206. doi: 10.1016/j.pnpbp.2013.02.015
- Li Hc, Chen Qz, Ma Y, Zhou J (2006) Imbalanced free radicals and antioxidant defense systems in schizophrenia: A comparative study. Journal of Zhejiang University - Science. B. 7 (12): 981-986. doi: 10.1631/ jzus.2006.B0981
- Mahadik SP, Scheffer RE (1996) Oxidative injury and potential use of antioxidants in schizophrenia. 55 (1-2): 45-54. doi: 10.1016/s0952-3278(96)90144-1
- Bajpai A, Verma AK, Srivastava M, Srivastava R (2014) Oxidative stress and major depression. Journal of Clinical and Diagnostic Research. 8 (12): CC04-CC07. doi: 10.7860/JCDR/2014/10258.5292
- Rawdin BS, Mellon, SH, Dhabhar FS, Epel ES, Puterman E, Su Y, Burke HM, Reus VI, Rosser R, Hamilton SP, Nelson JC, Wolkowitz OM (2013) Dysregulated relationship of inflammation and oxidative stress in major depression. Brain Behaviour and Immunity. 31: 143-152. doi: 10.1016/j.bbi.2012.11.011
- Lindqvist D, Dhabhar FS, James SJ, Hough CM, Jain FA, Bersani FS, Reus VI, Verhoeven JE, Epel ES, Mahan L, Rosser R, Wolkowitz OM, Mellon SH (2017) Oxidative stress, inflammation and treatment response in major depression. Psychoneuroendocrinology. 76: 197-205. doi: 10.1016/j.psyneuen.2016.11.031
- Wium-Andersen MK, Kobylecki CJ, Afzal S, Nordestgaard BG (2017) Association between the antioxidant uric acid and depression and antidepressant medication use in 96989 individuals. Acta Psychiatrica Scandinavica. 136 (4): 424-433. doi: 10.1111/acps.12793
- Wen S, Cheng M, Wang H, Yue J, Wang H, Li G, Zheng L, Zhong Z, Peng F (2012) Serum uric acid levels and the clinical characteristics of depression. Clinical Biochemistry. 45 (1-2): 49-53. doi: 10.1016/j.clinbiochem. 2011.10.010
- Meng X, Huang X, Deng W, Li J, Li T (2020) Serum uric acid a depression biomarker. PLoS One. 15 (3): e022 9626. doi: 10.1371/journal.pone.0229626
- Liu T, Zhong S, Liao X, Chen J, He T, Lai S, Jia Y (2015) A meta-analysis of oxidative stress markers in depression. PLoS One. 10 (10): e0138904. doi: 10.1371/journal.pone.0138904
- Jiménez-Fernández S, Gurpegui M, Díaz-Atienza F, Pérez-Costillas L, Gerstenberg M, Correll CU (2015) Oxidative stress and antioxidant parameters in patients with major depressive disorder compared to healthy controls before and after antidepressant treatment: results from a meta-analysis. Journal of Clinical Psychiatry. 76: 1658-1667. doi: 10.4088/JCP.14r09179
- Peela JR, Jarari AM, Sheriff DS, Salh EA, Hai A, Rawal AK, Zaidi SHH (2011) Serum uric acid levels as an adjunct in the assessment of certain psychiatric disorders in Libya. Journal of Basic Medical and Allied Sciences. https://www.academia.edu/28314112/serum_uric_acid.
- Pickard BS (2015) Schizophrenia biomarkers: Translating the descriptive into the diagnostic. Journal of Psycho-pharmacology. 29 (2): 138-143. doi: 10.1177/0269881114566631
- Yanik M, Erel O, Kati M (2004) The relationship between potency of oxidative stress and severity of depression. Acta Neuropsychiatrica. 16 (4): 200-203. doi: 10.1111/j.0924-2708.2004.00090.x
Submitted date:
06/02/2022
Reviewed date:
06/22/2022
Accepted date:
06/28/2022
Publication date:
11/08/2024