Brazilian Journal of Anesthesiology
https://app.periodikos.com.br/journal/rba/article/doi/10.1590/S0034-70942011000200014
Brazilian Journal of Anesthesiology
Review Article

Citocinas e dor

Cytokines and pain

Caio Marcio Barros de Oliveira; Rioko Kimiko Sakata; Adriana Machado Issy; Luis Roberto Gerola; Reynaldo Salomão

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Resumo

JUSTIFICATIVA E OBJETIVOS: As citocinas são substâncias necessárias para a resposta inflamatória, favorecendo a cicatrização apropriada da ferida. No entanto, a produção exagerada de citocinas pró-inflamatórias a partir da lesão pode manifestar-se sistemicamente com instabilidade hemodinâmica ou distúrbios metabólicos. O objetivo desta revisão foi descrever os efeitos das citocinas na dor. CONTEÚDO: Este artigo faz uma revisão dos efeitos das citocinas na dor. Em doenças que cursam com processo inflamatório agudo ou crônico, as citocinas podem ser reconhecidas por neurônios e utilizadas para desencadear diversas reações celulares que influenciam na atividade, proliferação e sobrevida da célula imunológica, bem como na produção e atividade de outras citocinas. As citocinas podem ser pró-inflamatórias e anti-inflamatórias. As pró-inflamatórias estão relacionadas com a fisiopatologia das síndromes dolorosas. Foram descritas as células que secretam as citocinas, as citocinas pró-inflamatórias (IL-1, IL-2, IL-6, IL-7 e FNT) e anti-inflamatórias (IL-4, IL-10, IL-13 e FTCβ), as funções de cada citocina e como ocorre a ação dessas substâncias no processamento da dor. CONCLUSÕES: As citocinas desempenham importante papel na dor, agindo através de diferentes mecanismos em vários locais das vias de transmissão da dor.

Palavras-chave

DOR, Citocinas

Abstract

BACKGROUND AND OBJECTIVES: Cytokines are necessary for the inflammatory response, favoring proper wound healing. However, exaggerated proinflammatory cytokine production can manifest systemically as hemodynamic instability or metabolic derangements. The objective of this review was to describe the effects of cytokines in pain. CONTENTS: This article reviews the effects of cytokines in pain. In diseases with acute or chronic inflammation, cytokines can be recognized by neurons and used to trigger several cell reactions that influence the activity, proliferation, and survival of immune cells, as well as the production and activity of other cytokines. Cytokines can be proinflammatory and anti-inflammatory. Proinflammatory cytokines are related with the pathophysiology of pain syndromes. Cells that secrete proinflammatory (IL-1, IL-2, IL-6, IL-7, and TNF) and anti-inflammatory (IL-4, IL-10, IL-13, and TGFβ) cytokines, the functions of each cytokine, and the action of those compounds on pain processing, have been described. CONCLUSIONS: Cytokines have an important role in pain through different mechanisms in several sites of pain transmission pathways.

Keywords

Cytokines, Interleukins, Nociceptors, Pain

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