Brazilian Journal of Anesthesiology
https://app.periodikos.com.br/journal/rba/article/doi/10.1590/S0034-70942003000400014
Brazilian Journal of Anesthesiology
Artigo de Revisão

Substâncias carreadoras de oxigênio à base de hemoglobina: situação atual e perspectivas

Hemoglobin-based blood substitutes: current status and perspectives

Pedro Paulo Tanaka; Maria Aparecida Almeida Tanaka

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Resumo

JUSTIFICATIVA E OBJETIVOS: Soluções alternativas à transfusão de sangue têm sido estudadas desde a década de 50. O objetivo deste estudo é apresentar a situação atual e as perspectivas futuras das substâncias carreadoras de oxigênio à base de hemoglobina. CONTEÚDO: São apresentadas as potenciais áreas de aplicação, bem como estudos clínicos envolvendo as principais moléculas de hemoglobina desenvolvidas, suas vantagens e limitações. CONCLUSÕES: Vários estudos aleatórios demonstraram eficácia com o propósito de evitar ou reduzir a transfusão sangüínea; entretanto, algumas limitações existem, sendo que o futuro substituto sangüíneo deverá, no mínimo, retratar a segurança e a eficácia do sangue em si.

Palavras-chave

SANGUE

Abstract

BACKGROUND AND OBJECTIVES: Alternatives to red blood cells transfusion have been studied since the fifties. This study aimed at presenting current status and perspectives of hemoglobin-based blood substitutes. CONTENTS: Potential application areas are presented, in addition to clinical studies involving major hemoglobin molecules developed, their advantages and limitations. CONCLUSIONS: Several randomized trials have shown efficacy in avoiding or decreasing red blood cells transfusions, however there are some limitations and the future blood substitute shall at least have the same safety and efficacy of blood itself.

Keywords

BLOOD

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