Intranasal dexmedetomidine: does the delivery device matter?
Eliane C.S. Soares, Paulo C.P. Figueiredo, Fabiano Soares Carneiro, Eduardo M.O. Melo e Silva, Patrícia B. Amaral
References
1. Rocha KO, Santos ERFA, Pombeiro MM, et al. Intranasal dexmedetomidine for procedural sedation in children: a systematic review and meta-analysis. Braz J Anesthesiol. 2026;76:844717.
2. Li BL, Zhang N, Huang JX, et al. A comparison of intranasal dexmedetomidine for sedation in children administered either by atomiser or by drops. Anaesthesia. 2016;71:522−8.
3. Xie Z, Shen W, Lin J, et al. Sedation effects of intranasal dexmedetomidine delivered as sprays versus drops on pediatric response to venous cannulation. Am J Emerg Med. 2017;35:1210−4.
4. Li A, Yuen VM, Goulay-Dufay S, et al. Pharmacokinetic and pharmacodynamic study of intranasal and intravenous dexmedetomidine. Br J Anaesth. 2018;120:960−8.
5. Wolfe TR, Braude DA. Intranasal medication delivery for children: a brief review and update. Pediatrics. 2010;126:532−7.
Submitted date:
05/06/2026
Accepted date:
06/21/2026
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