Exploring the analgesic effects of pregabalin for post-chikungunya arthralgia: a comparative double-blind study
Rodrigo Souza Rodrigues, Rioko Kimiko Sakata, William Vinicius da Silva, Camila Roberta Raimundo, Camila Fecury Cerqueira, Plinio da Cunha Leal
Abstract
Dear Editor,
Chikungunya represents a debilitating syndrome triggered by a homonymous virus. Its predominant clinical manifestation involves arthralgia coupled with physical limitations, mirroring rheumatoid arthritis. Despite the absence of disease-specific therapies, the joint pain accompanying chikungunya is inflammatory in nature and exhibits neuropathic characteristics. Pregabalin has displayed beneficial effects, even among patients not meeting neuropathic pain criteria. Notably, preceding research underscores the role of cytokines in the development of chikungunya-associated joint disease, akin to that seen in rheumatoid arthritis. This suggests potential benefits from immunomodulatory therapies such as hydroxychloroquine. Given the disease's prevalence and the consequent morbidity, the necessity for more efficacious treatment options for chronic chikungunya-related arthralgia remains unmet.
Supplementary materials
Supplementary material associated with this article can be found in the online version at doi: 10.1016/j.bjane.2023.09.002.
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Submitted date:
06/27/2023
Accepted date:
09/04/2023
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