Chronic pain after hospital discharge on patients hospitalized for COVID-19: an observational study
Dor crônica após alta hospitalar em pacientes internados por COVID-19: estudo observacional
Guilherme Antonio Moreira de Barros, Douglas Inomata Cardoso da Silva, Mariana Lopes Amaral Barbosa, Rafael Abbud Soares, Rodrigo Leal Alves, Claudio Lucas Miranda, Paula Danieli Lopes da Costa, Paulo do Nascimento Júnior, Norma Sueli Pinheiro Módolo
Abstract
Background
There are few studies related to Coronavirus Disease 2019 (COVID-19) on the prevalence and nature of pain symptoms after hospital discharge, especially in individuals who develop moderate to severe disease forms. Therefore, this study aimed to evaluate the presence of chronic pain in patients discharged after hospitalization for COVID-19, and the relationship between the presence of chronic pain and intensive care stay, demographics, and risk factors for the worst Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outcome.
Methods
A cross-sectional observational study was carried out on patients with COVID-19 who recovered after hospitalization. Patients were recruited at the least 3 months after discharge and their hospital's health files were prospected. The variables evaluated were demographics, the severity of SARS-CoV-2 infection (considering the need for intensive care), and the presence of chronic pain. The results were shown in a descriptive manner, and multivariate analysis expressed as Odds Ratios (ORs) and respective Confidence Intervals (CIs) for the outcomes studied. Statistical significance was set at p < 0.05.
Results
Of 242 individuals included, 77 (31.8%) reported chronic pain related to COVID-19, with no correlation with the severity of infection. Female sex and obesity were associated with a higher risk for chronic pain with ORs of 2.69 (Confidence Interval [95% CI 1.4 to 5.0]) and 3.02 (95% CI 1.5 to 5.9). The limbs were the most affected areas of the body.
Conclusion
Chronic pain is common among COVID-19 survivors treated in hospital environments. Female sex and obesity are risk factors for its occurrence.
Keywords
Resumo
Introdução
Existem poucos estudos relacionados à Doença do Coronavírus 2019 (COVID-19) sobre a prevalência e a natureza dos sintomas dolorosos após a alta hospitalar, especialmente em indivíduos que desenvolvem formas moderadas a graves da doença. Portanto, este estudo teve como objetivo avaliar a presença de dor crônica em pacientes que receberam alta após internação por COVID-19, e a relação entre a presença de dor crônica e internação em terapia intensiva, dados demográficos e fatores de risco para pior Síndrome Respiratória Aguda Grave Coronavírus 2 (SARS-CoV-2).
Métodos
Foi realizado um estudo observacional transversal em pacientes com COVID-19 que se recuperaram após hospitalização. Os pacientes foram recrutados pelo menos 3 meses após a alta e os arquivos de saúde do hospital foram prospectados. As variáveis avaliadas foram dados demográficos, gravidade da infecção por SARS-CoV-2 (considerando a necessidade de cuidados intensivos) e presença de dor crônica. Os resultados foram apresentados de forma descritiva e a análise multivariada expressa em Odds Ratios (OR) e respectivos Intervalos de Confiança (IC) para os desfechos estudados. A significância estatística foi estabelecida em p < 0,05.
Resultados
Dos 242 indivíduos incluídos, 77 (31,8%) relataram dor crônica relacionada à COVID-19, sem correlação com a gravidade da infecção. Sexo feminino e obesidade foram associados a um maior risco de dor crônica com OR de 2,69 (Intervalo de confiança [IC 95% 1,4 a 5,0]) e 3,02 (IC 95% 1,5 a 5,9). Os membros foram as áreas do corpo mais afetadas.
Conclusão
A dor crônica é comum entre sobreviventes de COVID-19 tratados em ambientes hospitalares. O sexo feminino e a obesidade são fatores de risco para sua ocorrência.
Palavras-chave
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Submetido em:
29/03/2023
Aceito em:
01/08/2023
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