Assessment of main complications of regional anesthesia recorded in an acute pain unit in a tertiary care university hospital: a retrospective cohort
Avaliação das principais complicações da anestesia regional registradas em uma unidade de dor aguda em um hospital universitário terciário: uma coorte retrospectiva
Marta G. Campos, Ana R. Peixoto, Sara Fonseca, Francisca Santos, Cristiana Pinho, Diana Leite
Abstract
Background
Regional anesthesia has been increasingly used. Despite its low number of complications, they are associated with relevant morbidity. This study aims to evaluate the incidence of complications after neuraxial block and peripheral nerve block.
Methods
A retrospective cohort study was conducted, and data related to patients submitted to neuraxial block and peripheral nerve block at a tertiary university hospital from January 1, 2011 to December 31, 2017 were analyzed.
Results
From 10,838 patients referred to Acute Pain Unit, 1093(10.1%) had side effects or complications: 1039 (11.4%) submitted to neuraxial block and 54 (5.2%) to peripheral nerve block. The most common side effects after neuraxial block were sensory (48.5%) or motor deficits (11.8%), nausea or vomiting (17.5%) and pruritus (8.0%); The most common complications: 3 (0.03%) subcutaneous cell tissue hematoma, 3 (0.03%) epidural abscesses and 1 (0.01%) arachnoiditis. 204 of these patients presented sensory or motor deficits at hospital discharge and needed follow-up. Permanent peripheral nerve injury after neuraxial block had an incidence of 7.7:10,000 (0.08%). The most common side effects after peripheral nerve block were sensory deficits (52%) and 21 patients maintained follow-up due to symptoms persistence after hospital discharge.
Conclusion
Although we found similar incidences of side effects or even lower than those described, major complications after neuraxial block had a higher incidence, particularly epidural abscesses. Despite this, other serious complications, such as spinal hematoma and permanent peripheral nerve injury, are still rare.
Keywords
Resumo
Introdução: A anestesia regional tem sido cada vez mais utilizada. Apesar do baixo número de complicações, estão associadas a morbidade relevante. Este estudo tem como objetivo avaliar a incidência de complicações após bloqueio neuroaxial e bloqueio de nervo periférico. Métodos: Foi realizado um estudo de coorte retrospectivo e analisados os dados referentes aos pacientes submetidos a bloqueio neuroaxial e bloqueio de nervo periférico em um hospital universitário terciário no período de 1º de janeiro de 2011 a 31 de dezembro de 2017. Resultados: Dos 10.838 pacientes encaminhados à Unidade de Dor Aguda, 1.093 (10,1%) apresentaram efeitos colaterais ou complicações: 1.039 (11,4%) submetidos ao bloqueio neuroaxia e 54 (5,2%) ao bloqueio de nervo periférico. Os efeitos colaterais mais comuns após o bloqueio neuroaxial foram déficits sensoriais (48,5%) ou motores (11,8%), náuseas ou vômitos (17,5%) e prurido (8,0%); As complicações mais comuns: 3 (0,03%) hematoma de tecido celular subcutâneo, 3 (0,03%) abscessos epidurais e 1 (0,01%) aracnoidite. 204 desses pacientes apresentaram déficits sensoriais ou motores na alta hospitalar e necessitaram de acompanhamento. A lesão permanente de nervo periférico após bloqueio neuroaxial teve incidência de 7,7:10.000 (0,08%). Os efeitos colaterais mais comuns após bloqueio do nervo periférico foram déficits sensoriais (52%) e 21 pacientes mantiveram o acompanhamento devido à persistência dos sintomas após a alta hospitalar. Conclusão: Embora tenhamos encontrado incidências de efeitos colaterais semelhantes ou até inferiores às descritas, as complicações maiores após o bloqueio neuroaxial tiveram maior incidência, principalmente de abscessos epidurais. Apesar disso, outras complicações graves, como hematoma espinhal e lesão permanente de nervo periférico, ainda são raras.
Palavras-chave
References
1
M. Hutton, R. Brull, A. Macfarlane
Regional Anaesthesia and outcomes
BJA Education., 18 (2018), pp. 52-56
2
R. Brull, C. McCartney, V. Chan, et al.
Neurological complications after regional anesthesia: contemporary estimates of risk
Anesth Analg., 104 (2007), pp. 965-974
3
C. Kent, L. Bollag
Neurological adverse events following regional anesthesia administration
Local Reg Anesth., 3 (2010), pp. 115-123
4
J.M. Neal, M.J. Barrington, R. Brull, et al.
The Second ASRA Practice Advisory on Neurologic Complications Associated with Regional Anesthesia and Pain Medicine: Executive Summary 2015
Reg Anesth Pain Med., 40 (2015), pp. 401-430
5
M. Pitkanen, U. Aromaa, D. Cozanitis, et al.
Serious complications associated with spinal and epidural anaesthesia in Finland from 2000 to 2009
Acta Anaesthesiol Scan., 57 (2013), pp. 553-564
6
C. Cameron, D. Scott, W. McDonald, et al.
A Review of Neuraxial Epidural Morbidity: Experience of More Than 8,000 Cases at a Single Teaching Hospital
Anesthesiology., 106 (2007), pp. 997-1002
7
E. Bos, J. Haumann, M. Quelerij, et al.
Haematoma and abscess after neuraxial anaesthesia: a review of 647 cases
Br J Anaesth., 120 (2018), pp. 693-704
8
T.T. Horlocker, D.J. Wedel
Neurologic complications of spinal and epidural anesthesia
Reg Anesth Pain Med., 25 (2000), pp. 83-98
9
U. Naithani, D. Verma, S. Rajkumar, et al.
Lower limb weakness and paresthesia after combined spinal epidural anesthesia for abdominal hysterectomy: a report of three cases
Anaesth Pain Intensive Care., 19 (2015), pp. 187-191
10
E. Ganem, Y. Castiglia, P. Vianna
Spinal Anesthesia-induced Neurological Complications
Rev Bras Anestesiol., 52 (2002), pp. 471-480
11
T.W. Breen, T. Shapiro, B. Glass, et al.
Epidural anesthesia for labor in an ambulatory patient
Anesth Analg., 77 (1993), pp. 919-924
12
J.R. Hebl, T.T. Horlocker, S.L. Kopp, et al.
Neuraxial blockade in patients with preexisting spinal stenosis, lumbar disk disease, or prior spine surgery: efficacy and neurologic complications
Anesth Analg., 111 (2010), pp. 1511-1519
13
Y. Auroy, D. Benhamou, L. Bargues, et al.
Major Complications of Regional Anesthesia in France
Anesthesiology., 97 (2002), pp. 1274-1280
14
J. Markey, N. Osama, D. Bird, et al.
Transient Neurologic Symptoms After Epidural Analgesia
Anesth Analg., 90 (2000), pp. 437-439
15
M. Almeida, D. Shumaker, K. LeBlanc, et al.
Incidence of post-dural puncture headache in research volunteers
Headache., 51 (2011), pp. 1503-1510
16
B. Martinez, E. Canser, A. Alonso, et al.
Postdural puncture headache and epidural blood patch in a large obstetric anaesthesia population
Asian J Anesthesiol., 56 (2018), pp. 23-32
17
M. Harde, R. Bhadade, H. Iyer, et al.
A comparative study of epidural catheter colonization and infection in Intensive Care Unit and wards in a Tertiary Care Public Hospital
Indian J Crit Care Med., 20 (2016), pp. 109-113
18
T.M. Cook, D. Counsell, J.A. Wildsmith
Major complications of central neuraxial block: report on the Third National Audit Project of the Royal College of Anaesthetists
Br J Anaesth., 102 (2009), pp. 179-190
19
S. Grewal, G. Hocking, J. Wildsmith
Epidural abscesses
Br J Anaesth., 96 (2006), pp. 292-302
20
A. Agarwal, K. Kishore
Complications and controversies of regional anesthesia: a review
Indian J Anaesth., 53 (2009), pp. 543-553
21
V. Moen, N. Dahlgren, L. Irestedt
Severe neurological complications after central neuraxial blockade in Sweden 1990-1999
Anesthesiology., 101 (2004), pp. 950-959
22
D. Bogod
The sting in the tail: antiseptics and the neuroaxis revisite
Anaesthesia., 67 (2012), p. 1305
23
A. Sghirlanzoni, R. Marazzi, D. Pareyson, et al.
Epidural anaesthesia and spinal arachnoiditis
Anaesthesia., 44 (1989), p. 317
24
A. Borgeat, G. Ekatodramis, C.A. Schenker
Postoperative nausea and vomiting in regional anesthesia: a review
Anesthesiology., 98 (2003), pp. 530-547
25
K. Holte, N.B. Foss, C. Svensén, et al.
Epidural Anesthesia, Hypotension, and Changes in Intravascular Volume
Anesthesiology., 100 (2004), pp. 281-286
26
K. Kumar, S.I. Singh
Neuraxial opioid-induced pruritus: An update
J Anaesthesiol Clin Pharmacol., 29 (2013), pp. 303-307
27
S.S. Ladak, R. Katznelson, M. Muscat, et al.
Incidence of urinary retention in patients with thoracic patient-controlled epidural analgesia (TPCEA) undergoing thoracotomy
Pain Manag Nurs., 10 (2009), pp. 94-98
28
C.L. Jeng, T.M. Torrillo, M.A. Rosenblatt
Complications of peripheral nerve blocks
Br J Anaesth., 105 (2010), pp. 97-107
29
M. Pascual-Gallego, H. Zimman, A. Gil, et al.
Pseudomeningocele after traumatic nerve root avulsion. A novel technique to close the fistula
Interv Neuroradiol., 19 (2013), pp. 496-499
30
S. Munirama, G. McLeod
A systematic review and meta-analysis of ultrasound versus eletrical stimulation for peripheral nerve location and blockade
Anaesthesia, 70 (2015), pp. 1084-1091