Peripheral nerve block and rebound pain: literature review
Bloqueio de nervos periféricos e dor rebote: revisão de literatura
Layana Vieira Nobre, Graziella Prianti Cunha, Paulo César Castello Branco de Sousa, Alexandre Takeda, Leonardo Henrique Cunha Ferraro
Abstract
Background and objectives
To investigate, describe, and assess the phenomenon of “rebound pain” as a clinically relevant problem in anesthetic practice.
Content
The phenomenon of “rebound pain” has been demonstrated and described as a very severe pain, which occurs after a peripheral nerve block resolution with the recovery of sensitivity. The incidence of rebound pain is unknown. Usually, it occurs between 12 and 24 hours after surgery and, adversely affecting sleep quality. It is not yet possible to establish a mechanism as a definitive cause or trigger factor of rebound pain. Studies suggest that rebound pain is a side effect of peripheral nerve blocks, despite their effectiveness in pain control. Currently, the extent and clinical significance of rebound pain cannot be well determined due to the lack of large prospective studies.
Conclusion
Rebound pain assessment should always be considered in clinical practice, as it is not a rare side effect of peripheral nerve blocks. There are still many challenging questions to be answered about rebound pain, so large prospective studies are needed to address the issue. For prevention, the use of peripheral nerve block techniques that avoid nerve damage and adequate perioperative analgesia associated with patient education on the early administration of analgesics, even during the period of analgesia provided by peripheral nerve block, is recommended. A better understanding of the “rebound pain” phenomenon, its pathophysiology, associated risk factors, and long-term consequences may help in developing more effective preventive strategies.
Resumo
Keywords
Resumo
Justificativa e objetivos
Investigar, descrever e avaliar o fenômeno da “dor rebote” como um problema clinicamente relevante na prática anestésica.
Conteúdo
O fenômeno da “dor rebote” foi demonstrado e descrito como uma dor muito intensa que ocorre após a resolução do bloqueio de nervo periférico com o retorno da sensibilidade. A incidência de dor rebote é desconhecida. Normalmente ela ocorre entre 12 a 24 horas após a cirurgia e afeta negativamente a qualidade do sono. Ainda não é possível estabelecer um mecanismo como causa definitiva ou fator desencadeante da dor rebote. Estudos sugerem que a dor rebote seja um efeito colateral dos bloqueios de nervos periféricos, apesar destes terem eficácia no controle álgico. Atualmente, a extensão e a significância clínica da dor rebote não podem ser bem determinadas, devido à falta de grandes estudos prospectivos.
Conclusão
A avaliação da dor rebote deve ser sempre considerada na prática clínica, pois não é um efeito colateral raro dos bloqueios de nervo periféricos. Ainda existem muitas questões desafiadoras a serem respondidas sobre a dor rebote, portanto fazem-se necessários amplos estudos prospectivos sobre a temática. Para a sua prevenção recomenda-se o uso de técnicas de bloqueio de nervo periférico que evitem a lesão do nervo e uma adequada analgesia perioperatória associada à orientação do paciente sobre a administração precoce de analgésicos mesmo na vigência da analgesia proporcionada pelo bloqueio de nervo periférico. A melhor compreensão do fenômeno “dor rebote”, sua fisiopatologia, seus fatores de risco associados e suas consequências em longo prazo poderá ajudar na elaboração de estratégias preventivas mais eficazes.
Palavras-chave
References
1 T.J. Gan, A.S. Habib, T.E. Miller, et al. Incidence, patient satisfaction, and perceptions of post-surgical pain: results from a US national survey Curr Med Res Opin, 30 (2014), pp. 149-160
2 J.L. Apfelbaum, C. Chen, S.S. Mehta, et al. Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged Anesth Analg, 97 (2003), pp. 534-540
3 H.F. Gramke, J.M. de Rijke, M. van Kleef, et al. Predictive factors of postoperative pain after day-case surgery Clin J Pain, 25 (2009), pp. 455-460
4 S.A. Grant, K.C. Nielsen, R.A. Greengrass, et al. Continuous peripheral nerve block for ambulatory surgery Reg Anesth Pain Med, 26 (2001), pp. 209-214
5 C.M. Court-Brown, J. McBirnie, G. Wilson Adult ankle fractures – an increasing problem? Acta Orthop Scand, 69 (1998), pp. 43-47
6 G. Joshi, K. Gandhi, N. Shah, et al. Peripheral nerve blocks in the management of postoperative pain: challenges and opportunities J Clin Anesth, 35 (2016), pp. 524-529
7 J.H. Oh, W.S. Kim, J.Y. Kim, et al. Continuous intralesional infusion combined with interscalene block was effective for postoperative analgesia after arthroscopic shoulder surgery J Shoulder Elbow Surg, 16 (2007), pp. 295-299
8 K.A. Egol, M.G. Soojian, M. Walsh, et al. Regional anesthesia improves outcome after distal radius fracture fixation over general anesthesia J Orthop Trauma, 26 (2012), pp. 545-549
9 J.M. Richman, S.S. Liu, G. Courpas, et al. Does continuous peripheral nerve block provide superior pain control to opioids?. A meta-analysis Anesth Analg, 102 (2006), pp. 248-257
10 J.R. DeMarco, R. Componovo, W.R. Barfield, et al. Efficacy of augmenting a subacromial continuous-infusion pump with a preoperative interscalene block in outpatient arthroscopic shoulder surgery: a prospective, randomized, blinded, and placebo-controlled study Arthroscopy, 27 (2011), pp. 603-610
11 B.A. Williams, M.T. Bottegal, M.L. Kentor, et al. Rebound pain scores as a function of femoral nerve block duration after anterior cruciate ligament reconstruction: retrospective analysis of a prospective, randomized clinical trial Reg Anesth Pain Med, 32 (2007), pp. 186-192
12 R.Y. Goldstein, N. Montero, S.K. Jain, et al. Efficacy of popliteal block in postoperative pain control after ankle fracture fixation: a prospective randomized study J Orthop Trauma, 26 (2012), pp. 557-561
13 A. Janda, R. Lydic, K.B. Welch, et al. Thermal hyperalgesia after sciatic nerve block in rat is transient and clinically insignificant Reg Anesth Pain Med, 38 (2013), pp. 151-154
14 L.M. Kolarczyk, B.A. Williams Transient heat hyperalgesia during resolution of ropivacaine sciatic nerve block in the rat Reg Anesth Pain Med, 36 (2011), pp. 220-224
15 B.A. Williams Forecast for perineural analgesia procedures for ambulatory surgery of the knee, foot, and ankle: applying patient-centered paradigm shifts Int Anesthesiol Clin, 50 (2012), pp. 126-142
16 D.K. Galos, D.P. Taormina, A. Crespo, et al. Does brachial plexus blockade result in improved pain scores after distal radius fracture fixation?. A randomized trial Clin Orthop Relat Res, 474 (2016), pp. 1247-1254
17 F.W. Abdallah, S.H. Halpern, K. Aoyama, et al. Will the real benefits of single-shot interscalene block please stand up?. A systematic review and meta-analysis Anesth Analg, 120 (2015), pp. 1114-1129
18 Y. Kamiya, M. Hasegawa, T. Yoshida, et al. Impact of pectoral nerve block on postoperative pain and quality of recovery in patients undergoing breast cancer surgery: a randomised controlled trial Eur J Anaesthesiol, 35 (2018), pp. 215-223
19 P. Lavand’homme Rebound pain after regional anesthesia in the ambulatory patient Curr Opin Anaesthesiol, 31 (2018), pp. 679-684
20 A. Borgeat Single-shot interscalene block: light and shadows Anesth Analg, 120 (2015), pp. 995-996
21 R. Sort, S. Brorson, I. Gogenur, et al. Rebound pain following peripheral nerve block anaesthesia in acute ankle fracture surgery: an exploratory pilot study Acta Anaesthesiol Scand, 63 (2018), pp. 396-402
22 M.J. Henningsen, R. Sort, A.M. Moller, et al. Peripheral nerve block in ankle fracture surgery: a qualitative study of patients’ experiences Anaesthesia, 73 (2018), pp. 49-58
23 A. Ganta, D. Ding, N. Fisher, et al. Continuous infraclavicular brachial block versus single-shot nerve block for distal radius surgery: a prospective randomized control trial J Orthop Trauma, 32 (2018), pp. 22-26
24 J.B. Knight, N.J. Schott, M.L. Kentor, et al. Neurotoxicity of common peripheral nerve block adjuvants Curr Opin Anaesthesiol, 28 (2015), pp. 598-604
25 M. Verlinde, M.W. Hollmann, M.F. Stevens, et al. Local anesthetic-induced neurotoxicity Int J Mol Sci, 17 (2016), p. 339
26 J. Ochroch, B.A. Williams Rebound pain after a nerve block wears off ASRA NEWS (2018)
27 O.S. Malik, A.D. Kaye, R.D. Urman Perioperative hyperalgesia and associated clinical factors Curr Pain Headache Rep, 21 (2017), p. 4
28 A.M. Gelineau, M.R. King, K.S. Ladha, et al. Intraoperative esmolol as an adjunct for perioperative opioid and postoperative pain reduction: a systematic review, meta-analysis, and meta-regression Anesth Analg, 126 (2018), pp. 1035-1049
29 T.M. Huynh, E. Marret, F. Bonnet Combination of dexamethasone and local anaesthetic solution in peripheral nerve blocks: a meta-analysis of randomised controlled trials Eur J Anaesthesiol, 32 (2015), pp. 751-758
30 K. Watanabe, J. Tokumine, T. Yorozu, et al. Particulate-steroid betamethasone added to ropivacaine in interscalene brachial plexus block for arthroscopic rotator cuff repair improves postoperative analgesia BMC Anesthesiol, 16 (2016), p. 84
31 K. El-Boghdadly, R. Brull, H. Sehmbi, et al. Perineural dexmedetomidine Is more effective than clonidine when added to local anesthetic for supraclavicular brachial plexus block: a systematic review and meta-analysis Anesth Analg, 124 (2017), pp. 2008-2020
32 K. An, N.M. Elkassabany, J. Liu Dexamethasone as adjuvant to bupivacaine prolongs the duration of thermal antinociception and prevents bupivacaine-induced rebound hyperalgesia via regional mechanism in a mouse sciatic nerve block model PLoS One, 10 (2015), p. e0123459
33 M. Desmet, H. Braems, M. Reynvoet, et al. I.V. and perineural dexamethasone are equivalent in increasing the analgesic duration of a single-shot interscalene block with ropivacaine for shoulder surgery: a prospective, randomized, placebo-controlled study Br J Anaesth, 111 (2013), pp. 445-452
34 M. Baeriswyl, K.R. Kirkham, A. Jacot-Guillarmod, et al. Efficacy of perineural vs systemic dexamethasone to prolong analgesia after peripheral nerve block: a systematic review and meta-analysis Br J Anaesth, 119 (2017), pp. 183-191
35 B.A. Williams, J.W. Ibinson, M.P. Mangione, et al. Research priorities regarding multimodal peripheral nerve blocks for postoperative analgesia and anesthesia based on hospital quality data extracted from over 1,300 cases (2011–2014) Pain Med, 16 (2015), pp. 7-12
36 S. Ko, S. Chae, W. Choi, et al. Prolonged pain reducing effect of sodium hyaluronate-carboxymethyl cellulose solution in the selective nerve root block (SNRB) of lumbar radiculopathy: a prospective, double-blind, randomized controlled clinical trial Spine J, 19 (2018), pp. 578-586
37 S.B. Ko, A.R. Vaccaro, H.J. Chang, et al. An evaluation of the effectiveness of hyaluronidase in the selective nerve root block of radiculopathy: a double blind, controlled clinical trial Asian Spine J, 9 (2015), pp. 83-89
38 A. Fisher, Y. Meller Continuous postoperative regional analgesia by nerve sheath block for amputation surgery – a pilot study Anesth Analg, 72 (1991), pp. 300-303
39 J.E. Chelly, L. Delaunay, B. Williams, et al. Outpatient lower extremity infusions Best Pract Res Clin Anaesthesiol, 16 (2002), pp. 311-320
40 D.Y. Ding, A. Manoli 3rd, D.K. Galos, et al. Continuous popliteal sciatic nerve block versus single injection nerve block for ankle fracture surgery: a prospective randomized comparative trial J Orthop Trauma, 29 (2015), pp. 393-398
41 J.H. Kim, H.J. Koh, D.K. Kim, et al. Interscalene brachial plexus bolus block versus patient-controlled interscalene indwelling catheter analgesia for the first 48 hours after arthroscopic rotator cuff repair J Shoulder Elbow Surg, 27 (2018), pp. 1243-1250
42 J.J. Lee, D.Y. Kim, J.T. Hwang, et al. Effect of ultrasonographically guided axillary nerve block combined with suprascapular nerve block in arthroscopic rotator cuff repair: a randomized controlled trial Arthroscopy, 30 (2014), pp. 906-914
43 J.J. Lee, J.T. Hwang, D.Y. Kim, et al. Effects of arthroscopy-guided suprascapular nerve block combined with ultrasound-guided interscalene brachial plexus block for arthroscopic rotator cuff repair: a randomized controlled trial Knee Surg Sports Traumatol Arthrosc, 25 (2017), pp. 2121-2128
44 A. Stathellis, W. Fitz, C. Schnurr, et al. Periarticular injections with continuous perfusion of local anaesthetics provide better pain relief and better function compared to femoral and sciatic blocks after TKA: a randomized clinical trial Knee Surg Sports Traumatol Arthrosc, 25 (2017), pp. 2702-2707
45 Y.S. Youm, S.D. Cho, H.Y. Cho, et al. Preemptive femoral nerve block could reduce the rebound pain after periarticular injection in total knee arthroplasty J Arthroplasty, 31 (2016), pp. 1722-1726
46 S. Namdari, T. Nicholson, J. Abboud, et al. Randomized controlled trial of interscalene block compared with injectable liposomal bupivacaine in shoulder arthroplasty J Bone Joint Surg Am, 99 (2017), pp. 550-556
47 D. Fletcher, U.M. Stamer, E. Pogatzki-Zahn, et al. Chronic postsurgical pain in Europe: an observational study Eur J Anaesthesiol, 32 (2015), pp. 725-734
48 S.S. Liu, W.M. Strodtbeck, J.M. Richman, et al. A comparison of regional versus general anesthesia for ambulatory anesthesia: a meta-analysis of randomized controlled trials Anesth Analg, 101 (2005), pp. 1634-1642
49 P. Mavridou, V. Dimitriou, A. Manataki, et al. Patient's anxiety and fear of anesthesia: effect of gender, age, education, and previous experience of anesthesia. A survey of 400 patients J Anesth, 27 (2013), pp. 104-108
50 R. Sort, S. Brorson, I. Gogenur, et al. An ankle trial study protocol: a randomised trial comparing pain profiles after peripheral nerve block or spinal anaesthesia for ankle fracture surgery BMJ Open, 7 (2017), p. e016001