Avaliação toxicológica do óleo essencial de Cymbopogon citratus (DC) stapf (Capim-Marinho) em camundongos e ratos
Toxicological evaluation of essential oil of Cymbopogon citratus (DC) stapf in mice and rats
Anderson Bentes de Lima, Pedro Iuri Castro da Silva, José da Costa Bastos Junior, Alessandra Souto Cardoso, Luciana Mota Silva, Renata Cunha Silva, Carlos Augusto Lima Barros, Jofre Jacob da Silva Freitas
Resumo
Este trabalho teve como objetivo a avaliação da toxicidade aguda e subcrônica do óleo essencial de Cymbopogon citratus (DC) stapf através da determinação da DL50 em camundongos e a análise dos parâmetros bioquímicos e hematológicos em ratos. A planta é utilizada na medicina popular da região amazônica em diversas doenças. O óleo essencial desta planta apresenta como constituinte principal o citral, (com propriedades ansiolítica, hipnótica, anticonvulsivante e fungicida). A DL50 do óleo essencial foi de 3000±91,32 mg/kg, sendo que este não alterou de maneira significativa os parâmetros bioquímicos e hematológicos em relação ao grupo controle. O valor da DL50 e os resultados observados nos parâmetros hematológicos e bioquímicos sugerem que o óleo essencial de Cymbopogon citratus apresenta uma toxicidade baixa.
Palavras-chave
Abstract
The aim of this work was the acute and sub-acute toxicological evaluation of the essential oil of Cymbopogon citratus (DC) stapf with the determination of the LD50 in mice and the analysis of their biochemical and haematological parameters in rats. The plant is used in the Amazon folk medicine for several diseases and in their essential oil the citral is the main constituent, presenting anxiolytic, sedative, anticonvulsive and fungicide properties. The LD50 was 3000±91.32 mg/kg, the essential oil do not change significantly the biochemical and hematological parameters when compared with the control group. The LD50 and the biochemical and haematological results have suggested that the essential oil of Cymbopogon citratus presented a low toxicity.
Keywords
Referências
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