In Vitro Degradation of Poly (L-co-D,L lactic acid) Containing PCL-T
Duarte, Marcia Adriana T.; Duek, Eliana A. R.; Motta, Adriana C.
http://dx.doi.org/10.4322/polimeros.2014.056
Polímeros: Ciência e Tecnologia, vol.24, n1, p.1-8, 2014
Abstract
The application of polymer-based bioresorbable temporary devices in the medical field grows continuously, and professionals from several areas act to solve problems related to body functions lost due to diseases, accidents or natural wear. Here we study the influence from poly(caprolactonetriol) (PCL-T) on the degeneration process in the copolymer poly(L-co-DL-lactic acid) (PLDLA) membrane, by producing PLDLA/PCL-T blends with 90/10, 70/30 and 50/50 relative concentrations. The data for in vitro degradation showed that PCL-T decreases the rate of PLDLA. This was obtained with the following techniques: Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), Gel Permeation Chromatography (GPC) and Scanning Electron Microscopy (SEM). Therefore, it is possible to vary the membrane degradation rate by changing the blend composition, which is a tool to tailor a biomaterial.
Keywords
Bioresorbable polymer, in vitro degradation, PLDLA/PCL-T.
References
1. Deng, M.; Nair, L. S.; Nukavarapu, S. P.; Kumbar, S. G.; Jiang, T.; Weikel, A. L.; Krogman, N. R.; Allcock, H. R. & Laurencin, C. T. - Adv. Funct. Mater., 20, p.2794 (2010). http://dx.doi.org/10.1002/adfm.201000968
2. Nampoothiri, K. M.; Nimisha, R. N. & Jonh, R. P. - Bioresour. Technol., 101, p.8493 (2010).
3. Park, K. I. & Xanthos, M. A. - Polym. Degrad. Stabil., 94, p.834 (2009). http://dx.doi.org/10.1016/j. polymdegradstab.2009.01.030
4. Walton, M. & Cotton, N. - J. Biomater. Appl., 21, p.395 (2007). http://dx.doi.org/10.1177/0885328206065125
5. Bret, D.; Ulery, L. S. N. & Cato, T. L. - J. Polym. Sci. Pol. Phys., 49, p.832 (2011).
6. Duarte, M. A. T. - “Influence of concentration of PCL-T membranes PLDLA: a study in vitro and in vivo”, PhD thesis, Mechanical Engineering, State University of Campinas (2009).
7. Maluf-Meiken, L. C. V.; Silva, D. R. M.; Duek, E. A. R. & Alberto-Rincon, M. C. - J. Mater. Sci: Mater. Med., 17, p.481 (2006).
8. Méier, M. M.; Kanis, L. A.; Lima, J. C; Pires, A. T. N. & Soldi, V. - Polym. Advanc. Technol., 15, p.593 (2004).
9. Balzer, O. S. - “Comparative Study of the Effect of Plasticizer polycaprolactones diol and triol and dioctyl phthalate in poly (vinyl chloride)”, PhD thesis, Federal University of Santa Catarina, Florianópolis (2009).
10. Motta, A. C. & Duek, E. A. R. - Polimeros, 17, p.123 (2007). http://dx.doi.org/10.1590/S0104-14282007000200011
11. Luciano, R. M.; Zavaglia, C. A. C.; Duek, E. A. R. & Alberto-Rincon, M. C. - J. Mater. Sci: Mater. Med., 14, p.87 (2003).
12. Baraúna, G. - “Peripheral nerve regeneration”, Dissertation, State University Campinas (2007).
13. Motta, A. C. & Duek, E. A. R. - Polimeros, 11, p.340 (2006).
14. Leiggener, C. S.; Curtis, R. & Rahn, B. A. - Biomaterials, 27, p.202 (2006). http://dx.doi. org/10.1016/j.biomaterials.2005.05.068
15. Zou, T.; Cheng, S. X.; Zhang, X. Z. & Zhang, R. X. - J. Biomed. Mater. Res. Part B: Appl. Biomater., 82B, p.400 (2007). http://dx.doi.org/10.1002/jbm.b.30745
16. Tsuyi, H. & Miyauchi, S. Poly (L-lactide) – Polym. Degrad. Stabil., 71, p.415 (2001).
17. Pezzin, A. P. T.; Alberda van Ekenstein, G. O. R. & Duek, E. A. R. - Polymer, 42, p.8303 (2001). http://dx.doi. org/10.1016/S0032-3861(01)00273-7
18. Hou, R.; Wu, L.; Wang, J. & Huang, N. - Appl. Surface Sci., 256, p.5000 (2010). http://dx.doi.org/10.1016/j. apsusc.2010.03.042
19. Lam, K. H.; Nieuwenhuis, P.; Molenaar, I.; Esselbrugge, H.; Feijen, J.; Dijkstra, P. J. & Schakenraad, J.M. - J. Mater. Sci: Mater. Med., 5, p.181 (1994). http://dx.doi. org/10.1007/BF00121086
20. Li, S. - J. Biomed. Mater. Res., 48, p.342 (1999). http://dx.doi. org/10.1002/(SICI)1097-4636(1999)48:3<342::AIDJBM20> 3.0.CO;2-7