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Mediterranean Journal of Pharmacy and Pharmaceutical Sciences
https://app.periodikos.com.br/journal/medjpps/article/doi/10.5281/zenodo.6399498

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences

Original article

Hematological consequences of antiepileptic drug therapy among children with epilepsy

Mudafara Bengleil, Faisa Alzunni, Seham Shaboun, Mohamed Almiahuob

http://dx.doi.org/10.5281/zenodo.6399498 Mediterr J Pharm Pharm Sci, vol.2, n1, p.44-52, 2022
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Abstract

Epilepsy is a chronic neurologic disease that comes third after cerebrovascular and Alzheimer’s disease. Anti-epileptic drugs may affect certain hematological parameters of epileptic patients. Few researchers investigated the hematological adverse effects of antiepileptic drugs in Libya. Thus, the aim was to evaluate hematological parameters in epileptic children who are on antiepileptic drugs. This retrospective study included 83 pediatric patients with epilepsy recruited from Benghazi Children's Hospital, Department of Neurology, from December 2017 to April 2018. Data collected included demographic characteristics, types of epilepsy, anti-epileptic drugs and serum hematological parameters. Hematological parameters recorded included: hemoglobin, hematocrit, platelet, mean cell volume, mean cell hemoglobin, mean cell hemoglobin concentration and white blood cell count. In all treated patients, regardless of the number of antiepileptic drugs therapy used, the average levels of hematological parameters were significantly lower in the treated group compared to the control group (11.64 gm per dl, 34.53%, 27.74 pg and 33.13 gm per dl, respectively). A significant increase (12.12109 per l) in white blood cell counts in the treated group was found. Average hemoglobin, hematocrit and mean cell hemoglobin concentration levels were significantly lower in patients on poly-therapy compared to mono-therapy and control groups. Average white blood cell counts were significantly increased in patients on anti-epileptic drugs. In sodium valproate users, levels of hematological parameters were significantly decreased but significantly increased in white blood cell counts. In diazepam users, significant increases in white blood cells and platelets but no difference in other parameters were observed. There were no differences in all hematological parameters among patients using carbamazepine except for platelet counts (significantly decreased). In conclusion, there is the substantial effect of the anti-epileptic drugs, especially sodium valproate, on the hematological parameters of children despite the effects were not critical as the changes were still in the normal range.

Keywords

Anti-epileptic, child, drug therapy, hematological parameters, Libya

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Submitted date:
01/10/2022

Reviewed date:
02/13/2022

Accepted date:
02/20/2022

Publication date:
11/19/2025

691e4b66a9539546ce45b664 medjpps Articles
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