Effective knowledge and practice regarding diabetic foot care among diabetic patients are crucial in reducing the risk of complications of foot ulcers and amputations. This cross-sectional study evaluates the levels of knowledge and practice of diabetic foot standards of care among Libyan diabetic patients. Thus, a total of 481 Libyan patients participated in 2024. Data were collected through a validated self-designed questionnaire that assessed foot care knowledge and practice. Scores were assigned for each yes response, and a median score was calculated to categorize participants as having good or poor knowledge and practice. The association between socio-demographic and diabetes-related factors with knowledge and practice was analyzed using the Chi-square test. The findings revealed that 74.1% of the participants had poor knowledge about the standards of diabetic foot care and 72.0% demonstrated poor practice related to diabetic foot care. A significant association was found between variables such as age, gender, and diabetes duration with knowledge and practice (p<0.05). 36.2%, reported having received formal education on diabetic foot care. This study recommends enhancing educational efforts and increasing physician involvement in foot care strategies. The majority of Libyan diabetic patients demonstrate a lack of knowledge and poor practice regarding diabetic foot care, which increases their risk of foot ulcers and amputations. This situation highlights the urgent need for an enhanced educational campaign focused on foot hygiene and care, as well as increased involvement of healthcare providers to deliver clear practical guidance preventing and an early examination to avoid complications in clinical practice.