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Mediterranean Journal of Pharmacy and Pharmaceutical Sciences
https://app.periodikos.com.br/journal/medjpps/article/doi/10.5281/zenodo.14876111

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences

Short communication

Bio-reducing properties of bryophyllum pinnatum aqueous leaves extract for the mediated synthesis of nickel oxide nanoparticles and its antimicrobial activities

Oluwaseyi Bukky Ovonramwen, Tega Destiny Oghenevurie, Ikhazuagbe Hilary Ifijen, Monday Idiaghe Imafidon, Imuentinyan Eriamiatoe

http://dx.doi.org/10.5281/zenodo.14876111 Mediterr J Pharm Pharm Sci, Ahead of Print, 2025
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Abstract

Bryophyllum pinnatum is a medicinal plant from the Crassulaceae family. It's traditionally used in Ayurvedic and folk medicine to cure various ailments, and its phytochemicals are used in the reduction of metal ions to produce nanoparticles. This study is aimed at the biosynthesis of nickel oxide nanoparticles using Bryophyllum pinnatum as a reducing, capping, and stabilizing agent, characterizing the synthesized nanoparticles, and studying the anti-microbial activity against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and Pseudomonas aeruginosa as well as fungi; Candida albicans, and Aspergillus niger. The synthesized nanoparticle was confirmed by UV-VIS, FT-IR, SEM-EDX, and XRD. The UV-VIS indicated the presence of chromophore and a surface plasmon resonance occurring in the sample with a band gap of 4.38 eV. The FT-IR result revealed the stretching vibration of the Ni-O bonds at 715 cm-1. The SEM analysis showed the morphology of the nanoparticles, and the EDX revealed that NiO-NPs are composed of oxygen and nickel elements. The XRD confirmed a face-centered cubic structure with an average size of 16.377 nm. The antimicrobial analysis exhibited the tested minimum concentration against all the bacterial strains. The synthesized Nickel oxide nanoparticles are useful in inhibiting the growth of different types of bacteria.

Keywords

Antimicrobial resistance, biosynthesis, capping agent leaf extract, nickel sulphate heptahydrate

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Submitted date:
01/16/2025

Reviewed date:
02/04/2025

Accepted date:
02/14/2025

Publication date:
02/15/2025

67b0d090a953955dd21f4864 medjpps Articles
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