Glycosylated hemoglobin in type 2 diabetic patients as a biomarker for predicting dyslipidemia
Elmabruk A. Gamag, Ashraf M. Albakoush, Maha J. Rashed, Braah A. Kassab, Samar A. Albasha
http://dx.doi.org/10.5281/zenodo.13993737
Mediterr J Pharm Pharm Sci, Ahead of Print, 2024
Abstract
Type 2 diabetes mellites (T2DM) is a common complex disease with multiple factors contributing to its development and progression. Dyslipidemia refers to the abnormality of lipid metabolism, characterized by elevated levels of low-density lipoprotein (LDL), total cholesterol (TC), triglycerides (TG), and decreased levels of high-density lipoprotein (HDL). It is a major risk factor for cardiovascular disease in type 2 diabetic patients. This study aimed to evaluate the diagnostic value of glycosylated hemoglobin (HbA1c) and fasting blood glucose (FBG) in predicting the risk of developing diabetic dyslipidemia. 86 clinically diagnosed Libyan patients with type 2 diabetes mellitus (44 males: 42 females), 30 years and 70 years of age were engaged in this study. Levels of HbA1C, blood glucose, TC, TG, LDL, and HDL were performed using a Lntegra Cobas 400+ analyzer. The findings showed that HbA1c exhibits a significant positive correlation with TC and TG with no significant correlation with LDL and HDL levels. Thus, this study suggests that HbA1c can be used as a potential dual marker of glycemic control and dyslipidemia in type 2 diabetes mellitus.
Keywords
Diabetes mellitus, glycemic control, HbA1c, Libya, lipid profile
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Submitted date:
10/07/2024
Reviewed date:
10/22/2024
Accepted date:
10/25/2024
Publication date:
11/07/2024
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