30DEC

Libyan International Conference for Health Sciences

The First Libyan International Conference for Health Sciences (2024): Open University, Tripoli, Libya
Mediterranean Journal of Pharmacy and Pharmaceutical Sciences
https://app.periodikos.com.br/journal/medjpps/article/doi/10.5281/zenodo.11173840

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences

Original article

Effects of jatropha curcas root extracts on the metabolic profile of mature female rats

Ale Ayotunde Oladunni, Odesanmi Omolola Selina, Magbagbeola Olubunmi Abiola

http://dx.doi.org/10.5281/zenodo.11173840 Mediterr J Pharm Pharm Sci, vol.4, n2, p.23-29, 2024
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Abstract

Extracts from Jatropha curcas, a tropical shrub, serve as multi-purpose treatments in folk medicine. Previous studies have shown conflicting reports of the metabolic effects of the extract of this plant. This study assessed the effects of Jatropha curcas root extracts on metabolic parameters of female Wistar rats, including body weight, glycemic index, and lipid profile. The root extracts of Jatropha curcas in water and 80.0% ethanol were prepared using the Soxhlet extraction method. Four groups of mature rats (groups A-D) were administered varying doses of water or ethanol extracts once daily for 15 days. Another group (group E) served as a control and received no extract. After stopping extract administration, the rats were fasted for 18 hrs and sacrificed. A venous blood sample was collected from each group for analysis of lipid and glycemic profiles using spectrophotometry. Statistical analysis was performed and the value with P < 0.05 was regarded as significant. No significant difference was observed in the overall body weights of the rats of any group before and after the treatment. Furthermore, the rats that were administered with the root extracts (either water or ethanol) exhibited higher levels of fasting blood glucose and serum lipids compared to the rats in the control group. In conclusion, the root extracts of Jatropha curcas predispose the rats to hyperlipidemia action and hyperglycemia action.

Keywords

J. curcas, metabolic effects, hyperlipidemia, hyperglycemia

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Submitted date:
04/21/2024

Reviewed date:
05/05/2024

Accepted date:
05/10/2024

Publication date:
05/10/2024

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