30DEC

Libyan International Conference for Health Sciences

The First Libyan International Conference for Health Sciences (2024): Open University, Tripoli, Libya
Mediterranean Journal of Pharmacy and Pharmaceutical Sciences
https://app.periodikos.com.br/journal/medjpps/article/doi/10.5281/zenodo.10698581

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences

Review

A collective review of the synthetic approaches disclosed in prior patents to synthesize the renowned drug, Lamotrigine

Sanjay Sukumar Saralaya, Shridhara Kanakamajalu, Shashikumar Somashekar Hiriyalu

http://dx.doi.org/10.5281/zenodo.10698581 Mediterr J Pharm Pharm Sci, vol.4, n1, p.52-74, 2024
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Abstract

In this review work, we have extracted the essential details from prior patents about the synthesis of popular drug Lamotrigine. This initiative will provide a platform for the global researchers to invent new or innovate over the existing synthetic routes to isolate Lamotrigine with good yield and purity. The details of patents were sourced from “Google patents” search tool and the process specific details were elaborated with reaction schemes. In this context, twenty-four reactions schemes were tabulated for the better understanding of the disclosed ventures. The entire chronological exfoliation of details on the synthesis of Lamotrigine provides a clear evolutional vision of its synthetic flourish towards drug commercialization.

Keywords

Lamotrigine, synthesis, cyanation, condensation, cyclization, recrystallization

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Submitted date:
02/02/2024

Reviewed date:
02/20/2024

Accepted date:
02/23/2024

Publication date:
02/23/2024

65d8f353a9539561e508b5c3 medjpps Articles
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