Oxidative stress and inflammation contribute substantially to the various chronic diseases in the world. Many routine drugs are available and in use, but a large proportion of them produce undesirable effects. The study investigated the antioxidant and anti-inflammatory properties and sought to identify the likely compounds present in Tapinanthus bangwensis. Antioxidant activity was determined using thiobarbituric acid reactive species (TBARS) and hydrogen peroxide (H₂0₂) assays. Bovine Serum Albumin Denaturation (BSAD) and Anti-Proteinase (AP) tests were used to assess anti-inflammatory activity. Identification of the compounds was via gas-chromatography-Mass Spectroscopy (GC-MS), while using FTIR (Fourier transition Infrared) to analyze the functional groups. The TBARs result showed that the reference drug (ascorbic acid), ad HECF 1, exhibited a more substantial inhibition compared to HECF 2. Likewise, the reference drug showed a more substantial inhibitory activity on H₂0₂ compared to the fractions. But the inhibition level of HECF 1 increased compared to HECF 2. Aspirin demonstrated a more substantial anti-inflammatory effect compared to the fractions. But that of the HECF 2 was higher compared to the HECF 1. The FTIR result showed the presence of a Carbonyl group (C=O), hydroxyl (OH), and amine group (N-H), suggesting that phenols, carboxylic acids, and fatty acids were likely present. The GC-MS result showed four compounds with reports of antioxidant and anti-inflammatory activity: 2-Pentadecanone, 6, 10, 14-trimethyl, Octacosane, 2, 4-di-tert butyl phenol, and Phytol. Thus, these compounds may contribute to the traditional use of T. bangwensis in treating oxidative and inflammatory diseases.