The role of physical therapy in the treatment of lipedema: an integrative review of therapeutic strategies and the current clinical landscape
O papel da fisioterapia no tratamento do lipedema: uma revisão integrativa sobre estratégias terapêuticas e o panorama clínico atual
Débora Aparecida Oliveira Modena; Jaqueline Munaretto Timm Baiocchi; Elaine Caldeira de Oliveira Guirro
Abstract
Keywords
Resumo
O lipedema é uma doença crônica caracterizada pelo acúmulo desproporcional de tecido adiposo subcutâneo nos membros, poupando as mãos e os pés. É comumente associado a dor, hipersensibilidade, facilidade para hematomas, edema e nódulos fibróticos. Apesar da crescente conscientização, ainda não há consenso sobre abordagens terapêuticas baseadas em evidências. Esta revisão integrativa teve como objetivo identificar estratégias fisioterapêuticas descritas na literatura científica para a avaliação e o tratamento conservador do lipedema. Foram realizadas buscas nas bases de dados PubMed/MEDLINE, BVS, PEDro, Embase e Cochrane, seguidas de avaliação crítica e síntese das evidências, com uso de itens aplicáveis do checklist PRISMA-ScR como guia para o relato do processo de seleção dos estudos. Os resultados indicam que a fisioterapia desempenha um papel fundamental no tratamento conservador, particularmente por meio de terapia descongestiva complexa, terapia compressiva, exercícios, técnicas manuais e agentes eletrofísicos. Essas intervenções demonstram benefícios potenciais na redução da dor, melhora da função, controle do edema e prevenção da progressão da doença; no entanto, as evidências disponíveis ainda são limitadas, o que ressalta a necessidade de ensaios clínicos mais robustos para embasar a prática da fisioterapia baseada em evidências.
Palavras-chave
References
1 Allen EV, Hines EA Jr. Lipedema of the legs: a syndrome characterized by fat legs and orthostatic edema. Mayo Clin Proc. 1940;15(12):184-7.
2 Amato ACM, Amato FCM, Amato JLS, Benitti DA. Lipedema prevalence and risk factors in Brazil. J Vasc Bras. 2022;21:e20210198.
3 Wold LE, Hines EA Jr, Allen EV. Lipedema of the legs: a syndrome characterized by fat legs and edema. Ann Intern Med. 1951;34(5):1243-50.
4 World Health Organization.
5 Kamamoto F, Baiocchi JMT, Batista BN, Ribeiro RDA, Modena DAO, Gornati VC. Lipedema: exploring pathophysiology and treatment strategies – state of the art. J Vasc Bras. 2025;23:e20240025.
6 Child AH, Gordon KD, Sharpe P, et al. Lipedema: an inherited condition. Am J Med Genet A. 2010;152A(4):970-6.
7 Fife CE, Maus EA, Carter MJ. Lipedema: a frequently misdiagnosed and misunderstood fatty deposition syndrome. Adv Skin Wound Care. 2010;23(2):81-92.
8 van la Parra RFD, Deconinck C, Pirson G, Servaes M, Fosseprez P. Lipedema: what we don’t know. J Plast Reconstr Aesthet Surg. 2023;84:302-12.
9 Vyas A, Adnan G. Lipedema. Treasure Island (FL): StatPearls Publishing; 2023.
10 Bauer AT, von Lukowicz D, Lossagk K, et al. New insights on lipedema: the enigmatic disease of the peripheral fat. Plast Reconstr Surg. 2019;144(6):1475-84.
11 Buso G, Depairon M, Tomson D, Raffoul W, Vettor R, Mazzolai L. Lipedema: a call to action! Obesity (Silver Spring). 2019;27(10):1567-76.
12 Oxford Centre for Evidence-Based Medicine. Levels of evidence (March 2009). 2009 [cited 2025 Nov 24].
13 Souza MT, Silva MD, Carvalho R. Revisão integrativa: o que é e como fazer. Einstein (Sao Paulo). 2010;8(1):102-6.
14 Amato ACM, Amato FCM, Benitti DA, Santos RV. Tradução, adaptação cultural e validação do questionário de avaliação sintomática do lipedema (QuASiL). J Vasc Bras. 2020;19:e20200049.
15 Czerwińska M, Teodorczyk J, Hansdorfer-Korzon R. A scoping review of available tools in measurement of therapeutic outcomes in lipoedema. Int J Environ Res Public Health. 2022;19(12):7124.
16 Kruppa P, Georgiou I, Biermann N, Prantl L, Klein-Weigel P, Ghods M. Lipedema: pathogenesis, diagnosis, and treatment options. Dtsch Arztebl Int. 2020;117(22-23):396-403. PMid:32762835.
17 Szolnoky G, Nagy N, Kovács RK, et al. Complex decongestive physiotherapy decreases capillary fragility in lipedema. Lymphology. 2008;41(4):161-6. PMid:19306662.
18 Atan T, Bahar-Özdemir Y. The effects of complete decongestive therapy or intermittent pneumatic compression therapy or exercise only in the treatment of severe lipedema: a randomized controlled trial. Lymphat Res Biol. 2021;19(1):86-95.
19 Donahue PMC, Crescenzi R, Petersen KJ, et al. Physical therapy in women with early stage lipedema: potential impact of multimodal manual therapy, compression, exercise, and education interventions. Lymphat Res Biol. 2022;20(4):382-90.
20 Faerber G, Cornely M, Daubert C, et al. S2k guideline lipedema. J Dtsch Dermatol Ges. 2024;22(9):1303-15. PMid:39188170.
21 Schmeller W, Meier-Vollrath I. Lipedema. In: Weissleder H, Schuchhardt C, Baumeister RGH, editors. Lymphedema: diagnosis and therapy. 4th ed. Cologne: ViaVital Verlag; 2008. p. 294-323.
22 Herbst KL, Kahn LA, Iker E, et al. Standard of care for lipedema in the United States. Phlebology. 2021;36(10):779-96.
23 Czerwińska M, Teodorczyk J, Spychała D, Hansdorfer-Korzon R. The usefulness of the application of compression therapy among lipedema patients: pilot study. Int J Environ Res Public Health. 2023;20(2):914.
24 Paling I, Macintyre L. Survey of lipoedema symptoms and experience with compression garments. Br J Community Nurs. 2020;25(Suppl 4):S17-22.
25 Ricolfi L, Reverdito V, Gabriele G, et al. Micromassage compression leggings associated with physical exercise: pilot study and example of evaluation of the clinical and instrumental effectiveness of conservative treatment in lipedema. Life (Basel). 2024;14(7):854.
26 van Esch-Smeenge J, Damstra RJ, Hendrickx AA. Muscle strength and functional exercise capacity in patients with lipoedema and obesity: a comparative study. J Lymphoedema. 2017;12(1):27-31.
27 Esmer M, Schingale FJ, Unal D, Yazıcı MV, Güzel NA. Physiotherapy and rehabilitation applications in lipedema management: a literature review. Lymphology. 2020;53(2):88-95.
28 Annunziata G, Paoli A, Manzi V, et al. The role of physical exercise as a therapeutic tool to improve lipedema: a consensus statement from the Italian Society of Motor and Sports Sciences (SISMeS) and the Italian Society of Phlebology (SIF). Curr Obes Rep. 2024;13(4):667-79.
29 Herbst KL, Ussery C, Eekema A. Pilot study: whole body manual subcutaneous adipose tissue (SAT) therapy improved pain and SAT structure in women with lipedema. Horm Mol Biol Clin Investig. 2017;33(2):20170035.
30 Ibarra M, Eekema A, Ussery C, Neuhardt D, Garby K, Herbst KL. Subcutaneous adipose tissue therapy reduces fat by dual X-ray absorptiometry scan and improves tissue structure by ultrasound in women with lipoedema and Dercum disease. Clin Obes. 2018;8(6):398-406.
31 Siems W, Grune T, Voss P, Brenke R. Anti-fibrosclerotic effects of shock wave therapy in lipedema and cellulite. Biofactors. 2005;24(1-4):275-82.
32 Michelini S, Musa F, Vetrano M, et al. Defocused and radial shock wave therapy, mesotherapy, and kinesio taping effects in patients with lipedema: a pilot study. Lymphology. 2023;56(1):13-26.
33 Baxter GD, Liu L, Tumilty S, Petrich S, Chapple C, Anders JJ. Low level laser therapy for the management of breast cancer-related lymphedema: a randomized controlled feasibility study. Lasers Surg Med. 2018;50(9):924-32.
34 Chen HY, Tsai HH, Tam KW, Huang TW. Effects of photobiomodulation therapy on breast cancer-related lymphoedema: a systematic review and meta-analysis of randomized controlled trials. Complement Ther Med. 2019;47:102200.
35 Chiu ST, Lai UH, Huang YC, Leong CP, Chen PC. Effect of various photobiomodulation regimens on breast cancer-related lymphedema: a systematic review and meta-analysis. Lasers Med Sci. 2023;39(1):11.
36 Smoot B, Chiavola-Larson L, Lee J, Manibusan H, Allen DD. Effect of low-level laser therapy on pain and swelling in women with breast cancer-related lymphedema: a systematic review and meta-analysis. J Cancer Surviv. 2015;9(2):287-304.
37 Szolnoky G, Varga E, Varga M, Tuczai M, Dósa-Rácz É, Kemény L. Lymphedema treatment decreases pain intensity in lipedema. Lymphology. 2011;44(4):178-82. PMid:22458119.
38 Wright T, Scarfino CD, O’Malley EM. Effect of pneumatic compression device and stocking use on symptoms and quality of life in women with lipedema: a proof-in-principle randomized trial. Phlebology. 2023;38(1):51-61.
39 Herbst KL, Zelaya C, Sommerville M, Zimmerman T, McHutchison L. An advanced pneumatic compression therapy system improves leg volume and fluid, adipose tissue thickness, symptoms, and quality of life and reduces risk of lymphedema in women with lipedema. Life (Basel). 2025;15(5):725.
40 Schneider R. Low-frequency vibrotherapy considerably improves the effectiveness of manual lymphatic drainage (MLD) in patients with lipedema: a two-armed, randomized, controlled pragmatic trial. Physiother Theory Pract. 2020;36(1):63-70.
41 Peled AW, Kappos EA. Lipedema: diagnostic and management challenges. Int J Womens Health. 2016;8:389-95.
42 Forner Cordero I, Szolnoky G, Forner Cordero A, Kemény L. Lipedema: an overview of its clinical manifestations, diagnosis and treatment of the disproportional fatty deposition syndrome. Clin Obes. 2012;2(3-4):86-95.
43 Buck DW II, Herbst KL. Lipedema: a relatively common disease with extremely common misconceptions. Plast Reconstr Surg Glob Open. 2016;4(9):e1043.
44 Schingale FJ. Lymphoedema, lipoedema. Diagnosis and therapy. A guide for those affected. Hannover (Germany): Schlütersche Verlag GmbH & Co. KG; 2003.
45 Brorson H, Höijer P. Standardised measurements used to order compression garments can be used to calculate arm volumes to evaluate lymphoedema treatment. J Plast Surg Hand Surg. 2012;46(6):410-5.
46 Rasmussen JC, Aldrich MB, Fife CE, Herbst KL, Sevick-Muraca EM. Lymphatic function and anatomy in early stages of lipedema. Obesity (Silver Spring). 2022;30(7):1391-400.
47 Chachaj A, Dudka I, Jeziorek M, Sowicz M, Adaszyńska A, Szuba A. Lymphoscintigraphic alterations in lower limbs in women with lipedema in comparison to women with overweight/obesity. Front Physiol. 2023;14:1099555.
48 Avraham T, Clavin NW, Daluvoy SV, et al. Fibrosis is a key inhibitor of lymphatic regeneration. Plast Reconstr Surg. 2009;124(2):438-50.
49 Brorson H. From lymph to fat: complete reduction of lymphoedema. Phlebology. 2010;25(1_suppl, Suppl Suppl 1):52-63.
50 Balcombe L, Miller C, McGuiness W. Approaches to the application and removal of compression therapy: a literature review. Br J Community Nurs. 2017;22(10):S6-14.
51 Duhon BH, Phan TT, Taylor SL, Crescenzi RL, Rutkowski JM. Current mechanistic understandings of lymphedema and lipedema: tales of fluid, fat, and fibrosis. Int J Mol Sci. 2022;23(12):6621.
52 Kruppa P, Gohlke S, Łapiński K, et al. Lipedema stage affects adipocyte hypertrophy, subcutaneous adipose tissue inflammation and interstitial fibrosis. Front Immunol. 2023;14:1223264.
53 Zampell JC, Aschen S, Weitman ES, et al. Regulation of adipogenesis by lymphatic fluid stasis: part I. Adipogenesis, fibrosis, and inflammation. Plast Reconstr Surg. 2012;129(4):825-34.
54 Modena DAO, Guidi RM, Soares CD, Cazzo E, Chaim EA. Electromagnetic shock wave therapy in dermatology: microscopic analysis of its interaction with the possible reduction of adipose tissue in obese individuals. Surg Cosmet Dermatol. 2020;12(4):352-8.
55 Modena DAO, Soares CD, Candido EC, Chaim FDM, Cazzo E, Chaim EA. Effect of extracorporeal shock waves on inflammation and angiogenesis of integumentary tissue in obese individuals: stimulating repair and regeneration. Lasers Med Sci. 2022;37(2):1289-97.
Submitted date:
11/24/2025
Accepted date:
05/21/2026
