Efficacy in prenatal vitamin B12 supplementation preventing vitamin B12 deficiency in exclusively breastfed infants
Eficacia de la suplementación prenatal con vitamin B12 para prevenir la deficiencia de vitamin B12 en lactantes alimentados exclusivamente con leche materna
Eren Güzeloğlu, Bilge Doğan Taymur, Büşra Nükhet Pehlivanoğlu, Hüseyin Dağ
Abstract
Introduction: Vitamin B12 is essential for erythropoiesis, cell proliferation, nucleoprotein and myelin synthesis, and normal growth and development of cognitive functions.
Material and methods: A retrospective cohort follow-up study is planned to determine vitamin B12 levels and to reveal the symptoms that occur in deficiency. A complete blood count is conducted as part of the standard protocol for pregnant women (third trimester) of pregnancy. At six months of age, the infant's serum vitamin B12 level, iron concentration, ferritin level, and complete blood count are assessed. 70 mother-baby pairs were followed up over the period from 01/01/2021 to 01/01/2022. The infant cohort included 51.4% boys (n=36) and 48.6% girls (n=34).
Results: It was observed that 58.5% (n=41) of the mothers used multivitamin supplements, and 80% of them used iron medication. When the babies of mothers who took a multivitamin containing B12 were compared with the babies of other mothers, it was observed that there was a statistical significance in the B12 levels of the babies (p=0.012).
Discussion: The effects of B12 supplementation given to mothers on the intelligence development of children were investigated. It was hypothesised that the recommendation to provide routine vitamin B12 supplementation to mothers could be incorporated into the existing guidelines. The concept was initially proposed during the course of the study. It is our view that the administration of vitamin B12 supplements to mothers has a beneficial effect on the vitamin B12 levels of their babies, and that vitamin B12 supplementation should be provided to mothers. Studies conducted in our country and in the world show that keeping the vitamin B12 level high during pregnancy and lactation is important for the health of the mother and baby. It is therefore recommended that pregnant women receive vitamin B12 supplementation, with continued supplementation for the first six months postpartum.
Keywords
Resumen
Introducción: La vitamina B12 es esencial para la eritropoyesis, la proliferación celular, la síntesis de nucleoproteínas y mielina, y el crecimiento y desarrollo normales de las funciones cognitivas.
Material y métodos: Se planifica un estudio de seguimiento de cohorte retrospectiva para determinar los niveles de vitamina B12 y revelar los síntomas que ocurren en la deficiencia. Se realiza un hemograma completo como parte del protocolo estándar para mujeres embarazadas (tercer trimestre) del embarazo. A los seis meses de edad, se evalúa el nivel sérico de vitamina B12 del bebé, la concentración de hierro, el nivel de ferritina y el hemograma completo. Se realizó un seguimiento de 70 parejas madre-bebé durante el período del 01/01/2021 al 01/01/2022. La cohorte de bebés incluyó un 51,4% de niños (n = 36) y un 48,6% de niñas (n = 34).
Resultados: Se observó que el 58,5% (n = 41) de las madres usaban suplementos multivitamínicos y el 80% de ellas usaba medicación con hierro. Cuando se compararon los bebés de madres que tomaron un multivitamínico que contenía B12 con los bebés de otras madres, se observó que había una significación estadística en los niveles de B12 de los bebés (p = 0,012).
Discusión: Se investigaron los efectos de la suplementación de B12 administrada a las madres sobre el desarrollo de la inteligencia de los niños. Se planteó la hipótesis de que la recomendación de proporcionar una suplementación de vitamina B12 de forma rutinaria a las madres podría incorporarse a las directrices existentes. El concepto se propuso inicialmente durante el curso del estudio. En nuestra opinión, la administración de suplementos de vitamina B12 a las madres tiene un efecto beneficioso sobre los niveles de vitamina B12 de sus bebés, y que se debe proporcionar suplementación de vitamina B12 a las madres. Los estudios realizados en nuestro país y en el mundo muestran que mantener el nivel de vitamina B12 alto durante el embarazo y la lactancia es importante para la salud de la madre y el bebé. Por lo tanto, se recomienda que las mujeres embarazadas reciban suplementos de vitamina B12, con una suplementación continua durante los primeros seis meses después del parto.
Palabras clave
References
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Submitted date:
07/29/2024
Reviewed date:
10/23/2024
Accepted date:
11/18/2024
Publication date:
12/03/2024
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