Thrombotic microangiopathy secondary to Capnocytophaga canimorsus bacteremia
Microangiopatía trombótica secundaria a bacteriemia por Capnocytophaga canimorsus
Enrique Chicote-Álvarez, Javier Larreina-Pérez, Ada Esteban-Figuerola, Prisma Monserrat Hernández-Pérez, Isabel Mainar-Gil, Sergio Gómez-Camino, Adolfo Íñiguez-de Diego, Elisa Monfort-Lázaro, Íñigo Gastón-Najarro, Miriam Díez-Sáez
Abstract
Capnocytophaga canimorsus is an Anaerobic Gram-Negative bacterium present in the oral microbiology of cats and dogs. It can produce infections in humans, being capable of causing severe complications with the development of septic shock. There are known cases where this bacterium developed medical complications like thrombotic microangiopathy and disseminated intravascular coagulation. We have the case of 79 years old male that developed thrombotic microangiopathy and splenic infarction linked to bacteraemia by Capnocytophaga canimorsus. Due to its severity, it was necessary to start renal replacement therapy and several sessions of plasmapheresis with good evolution.
Keywords
Resumen
Capnocytophaga canimorsus es una bacteria anaerobia gramnegativa presente en la microbiología oral de gatos y perros. Puede producir infecciones en humanos, siendo capaz de provocar un diagnóstico severo con desarrollo de shock séptico. Existen casos descritos con complicaciones médicas como Microangiopatía Trombótica y Coagulación Intravascular Diseminada. Presentamos el caso de un varón de 79 años que desarrolló microangiopatía trombótica e infarto esplénico asociado a bacteriemia por Capnocytophaga canimorsus. Por su gravedad, fue necesario iniciar terapia de reemplazo renal y varias sesiones de plasmaféresis con buena evolución.
Palabras clave
References
1. Gaastra W, Lipman LJ. Capnocytophaga canimorsus. Vet Microbiol. 2010;140(3-4):339-46. doi: 10.1016/j.vetmic.2009.01.040.
2. Nakayama R, Miyamoto S, Tawara T, Aoyagi A, Oguro T, Kobayashi N, et al. Capnocytophaga canimorsus infection led to progressively fatal septic shock in an immunocompetent patient. Acute Med Surg. 2022;9(1):e738. doi: 10.1002/ams2.738.
3. Hundertmark M, Williams T, Vogel A, Moritz M, Bramlage P, Pagonas N, et al. Capnocytophaga canimorsus as Cause of Fatal Sepsis. Case Rep Infect Dis. 2019;2019:3537507. doi: 10.1155/2019/3537507.
4. Brichacek M, Blake P, Kao R. Capnocytophaga canimorsus infection presenting with complete splenic infarction and thrombotic thrombocytopenic purpura: a case report. BMC Res Notes. 2012;5:695. doi: 10.1186/1756-0500-5-695.
5. Tani N, Nakamura K, Sumida K, Suzuki M, Imaoka K, Shimono N. An Immunocompetent Case of Capnocytophaga canimorsus Infection Complicated by Secondary Thrombotic Microangiopathy and Disseminated Intravascular Coagulation. Intern Med. 2019;58(23):3479-82. doi: 10.2169/internalmedicine.3110-19.
6. Leiva J, del Pozo JL. [Fastidious gram-negative rods: HACEK group, Capnocytophaga and Pasteurella]. Enferm Infecc Microbiol Clin. 2017;35(Supl 3):29-43.
7. Butler T. Capnocytophaga canimorsus: an emerging cause of sepsis, meningitis, and post-splenectomy infection after dog bites. Eur J Clin Microbiol Infect Dis. 2015;34(7):1271-80. doi: 10.1007/s10096-015-2360-7.
8. Romero S, Sempere A, Gómez-Seguí I, Román E, Moret A, Jannone R, et al. Practice guidelines for the emergency treatment of thrombotic microangiopathy. Med Clin (Barc). 2018;151(3):123.e1-123.e9. doi: 10.1016/j.medcli.2018.01.013.
9. Scully M, Hunt BJ, Benjamin S, Liesner R, Rose P, Peyvandi F, et al. Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies. Br J Haematol. 2012;158(3):323-35. doi: 10.1111/j.1365-2141.2012.09167.x.
10. Smeets NJL, Fijnheer R, Sebastian S, De Mast Q. Secondary thrombotic microangiopathy with severely reduced ADAMTS13 activity in a patient with Capnocytophaga canimorsus sepsis: a case report. Transfusion. 2018;58(10):2426-9. doi: 10.1111/trf.14829.
11. Maezawa S, Kudo D, Asanuma K, Takekoshi D, Egashira R, Kushimoto S. Severe sepsis caused by Capnocytophaga canimorsus complicated by thrombotic microangiopathy in an immunocompetent patient. Acute Med Surg. 2016 23;4(1):97-100. doi: 10.1002/ams2.222.
Submitted date:
08/18/2023
Reviewed date:
11/07/2023
Accepted date:
11/15/2023
Publication date:
11/15/2023