Iberoamerican Journal of Medicine
https://app.periodikos.com.br/journal/iberoamericanjm/article/doi/10.5281/zenodo.3714992
Iberoamerican Journal of Medicine
Case Report

Acute mesenteric lymphadenitis revealing systemic lupus erythematosus

Salem Bouomrani, Ines Lamloum

Downloads: 1
Views: 1447

Abstract

Acute mesenteric lymphadenitis (AML) remains unusual during systemic lupus erythematosus (SLE), and only a few sporadic observations have been found in the medical literature. It may exceptionally be the first manifestation revealing SLE representing a real diagnostic and therapeutic challenge for clinicians (specific lupus manifestation or infectious complication?).
We report an original observation of isolated AML revealing SLE in a 29-year-old Tunisian woman without pathological medical history. She was explored for acute and febrile abdominal pain evolving for a week and not improved by symptomatic treatment. The somatic examination noted a fever at 38.5°C and a discrete diffuse abdominal tenderness. Biology showed a marked biological inflammatory syndrome, leukopenia at 3400/mm3, neutropenia at 1900/mm3, and lymphopenia at 1140/mm3 with no other abnormalities. The abdominal ultrasound and computed tomography objectified multiple large, hypoechoic, and richly vascularized on Doppler mesenteric lymph node compatible with the diagnosis of AML. Subsequent investigations concluded to SLE.
The patient was treated with systemic glucocorticoids and hydroxychloroquine with favorable outcome. No recurrence has been noted for two years.

Keywords

Acute mesenteric lymphadenitis; Systemic lupus erythematosus; Lymphadenitis; Mesenteric adenitis

References

1. Fawzy M, Edrees A, Okasha H, El Ashmaui A, Ragab G. Gastrointestinal manifestations in systemic lupus erythematosus. Lupus. 2016;25(13):1456-62. doi: 10.1177/0961203316642308.
2. Sran S, Sran M, Patel N, Anand P. Lupus enteritis as an initial presentation of systemic lupus erythematosus. Case Rep Gastrointest Med. 2014;2014:962735. doi: 10.1155/2014/962735.
3. Stoddard CJ, Kay PH, Simms JM, Kennedy A, Hughes P. Acute abdominal complications of systemic lupus erythematosus. Br J Surg. 1978;65(9):625-8. doi: 10.1002/bjs.1800650911.
4. Henc-Mitis J. Peritoneal symptoms in the initial stage of systemic lupus erythematosus. Wiad Lek. 1987;40(16):1131-3.
5. Radin R. Acute mesenteric and retroperitoneal lymphadenitis in systemic lupus erythematosus: case report. Abdom Imaging. 2001;26(4):411-3. doi: 10.1007/s002610000182.
6. Kitsanou M, Andreopoulou E, Bai MK, Elisaf M, Drosos AA. Extensive lymphadenopathy as the first clinical manifestation in systemic lupus erythematosus. Lupus. 2000;9(2):140-3. doi: 10.1191/096120300678828037.
7. Smith LW, Gelber AC, Petri M. Diffuse lymphadenopathy as the presenting manifestation of systemic lupus erythematosus. J Clin Rheumatol. 2013;19(7):397-9. doi: 10.1097/RHU.0b013e3182a6a924.
8. Al-Hashimi H, Bhowmik A. Generalised lymphadenopathy as the first manifestation of lupus nephritis. BMJ Case Rep. 2010;2010. doi: 10.1136/bcr.08.2009.2221.
9. Eisner MD, Amory J, Mullaney B, Tierney L Jr, Browner WS. Necrotizing lymphadenitis associated with systemic lupus erythematosus. Semin Arthritis Rheum. 1996;26(1):477-82. doi: 10.1016/s0049-0172(96)80028-x.
10. Macari M, Hines J, Balthazar E, Megibow A. Mesenteric adenitis: CT diagnosis of primary versus secondary causes, incidence, and clinical significance in pediatric and adult patients. AJR Am J Roentgenol. 2002;178(4):853-8. doi: 10.2214/ajr.178.4.1780853.
11. Kim SH, Kim SD, Kim HR, Yoon CH, Lee SH, Kim HY, et al. Intraabdominal cryptococcal lymphadenitis in a patient with systemic lupus erythematosus. J Korean Med Sci. 2005;20(6):1059-61. doi: 10.3346/jkms.2005.20.6.1059.
12. Fernandez SH. Kikuchi's lymphadenitis (necrotizing lymphadenitis) and systemic lupus erythematosus: a case report. Malays J Pathol. 2000;22(1):25-9.
13. Hammoudeh M, Siam AR. Recurrent peritonitis with ascites as the predominant manifestation of systemic lupus erythematosus. Clin Rheumatol. 1995;14(3):352-4. doi: 10.1007/bf02208353.
14. Bairy I, Berwal A, Prabhu M, Budania LS. Systemic Lupus Erythematosus with Acute Pancreatitis as an Initial Presentation. J Clin Diagn Res. 2018;12(9):OR01-OR03. doi: 10.7860/JCDR/2018/35404.12019.


Submitted date:
03/05/2020

Reviewed date:
03/17/2020

Accepted date:
03/18/2020

Publication date:
03/18/2020

5e721d4b0e8825a6434778f4 iberoamericanjm Articles
Links & Downloads

Iberoam J Med

Share this page
Page Sections