Escola Anna Nery Revista de Enfermagem
https://app.periodikos.com.br/journal/ean/article/doi/10.1590/2177-9465-EAN-2019-0042
Escola Anna Nery Revista de Enfermagem
Revisão

Drug safety among institutionalized elderly people: potential interactionsa

Seguridad medicamentosa en ajustes institucionalizados: potencial interacciones

Segurança medicamentosa em idosos institucionalizados: potenciais interações

Maria Lígia Silva Nunes Cavalcante; Renata Kelly Lopes de Alcântara; Isabelly Costa Lima de Oliveira; Samia Freitas Aires; Ana Lívia Araújo Girão; Rhanna Emanuela Fontenele Lima de Carvalho

http://dx.doi.org/10.1590/2177-9465-EAN-2019-0042 Esc. Anna Nery, vol.24, n1, e20190042, 2020
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Abstract

Objective: to identify the drug interactions among institutionalized elderly.

Method: retrospective and documentary study with a quantitative approach developed in two Long Stay Institutions for Elderly, located in northeastern Brazil. Drug interactions were identified by using Drug-Reax® software from the Micromedex database, and they were classified by severity, start time, and documentation.

Result: in the 286 analyzed prescriptions, 136 drug interactions were detected in both institutions, most of them classified as severe. The average number of drugs prescribed by the elderly was 4.5. In the analysis of Pearson's correlation, the number of drug interactions showed a statistically significant correlation with the time of institutionalization and with the amount of drugs administered on the day.

Conclusion and implications for practice: the high consumption of drugs and serious drug interactions detected with significant clinical repercussions was evidenced in the study. Knowledge of these interactions is essential for the establishment of preventive safety measures in pharmacotherapy.

Keywords

Drug Interactions; Health of the Elderly; Patient Safety

Resumen

Objetivo: Identificar las posibles interacciones medicamentosas en ancianos institucionalizados.

Metodo: Estudio documental, retrospectivo, con abordaje cuantitativo, desarrollado en dos Instituciones de Larga Permanencia para Ancianos, ubicada en el nordeste de Brasil. Las posibles interacciones medicamentosas, del tipo fármaco-fármaco, fueron identificadas utilizándose el software Drug-Reax® de la base de datos Micromedex, y clasificadas según la gravedad, el tiempo de inicio y la documentación.

Resultados: En las 286 prescripciones, se detectaron 136 interacciones medicamentosas en las dos instituciones, siendo la mayoría clasificada como severidad grave. La media de medicamentos prescritos por los ancianos fue 4,5. El número de interacciones medicamentosas presentó correlación estadísticamente significativa con el tiempo de institucionalización y con la cantidad de medicamentos administrados en el día.

Conclusión e implicaciones para la práctica: Se evidenció un alto consumo de fármacos y de potenciales interacciones medicamentosas graves con respuestas clínicas significativas. El conocimiento de estas interacciones es esencial para el establecimiento de medidas preventivas de seguridad en la farmacoterapia para esa población.

Palabras clave

Interacciones Medicamentosas; Salud del Anciano; Seguridad del Paciente

Palavras-chave

 Interações medicamentosas; Saúde do Idoso; Segurança do Paciente

Referências

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Submetido em:
19/02/2019

Aceito em:
30/07/2019

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