Autopsy and Case Reports
https://app.periodikos.com.br/journal/autopsy/article/doi/10.4322/acr.2024.508
Autopsy and Case Reports
Clinical Case Report

Laryngeal plasmacytoma in a patient with Down’s syndrome

Hassan Hodroj; Zahraa Saker; Zahraa Al Najjar; Hassane Choukr; Mohamad Reda Noureddine El Moussaoui

http://dx.doi.org/10.4322/acr.2024.508 Autops Case Rep, vol.14, e2024508, 2024
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Abstract

Extramedullary plasmacytoma is a rare localized plasma cell neoplasm typically found in soft tissues outside the bone marrow. Predominantly occurring in the head and neck region, particularly in the sinonasal and nasopharyngeal areas, it presents a diagnostic challenge due to its uncommon nature. Herein, we report a 38-year-old female patient with Down’s syndrome with a 2-year complaint of intermittent dysphonia, hoarseness, and progressive respiratory distress, including dyspnea, fatigue, and biphasic stridor. Examination via flexible laryngoscopy revealed a white lesion, prompting direct microscopic laryngeal surgery to excise a 1x1 cm mass. Histological findings confirmed the diagnosis as solitary extramedullary plasmacytoma. Notably, this represented the first documented case of laryngeal solitary extramedullary plasmacytoma in a patient with Down’s syndrome. This case underscores the importance of considering tumor development in the larynx among individuals with Down’s syndrome, highlighting the necessity for tailored management strategies to address such occurrences effectively. Increasing awareness of this association can aid in early detection and appropriate treatment of tumors in this population.

Keywords

Extramedullary plasmacytoma, laryngeal neoplasms, larynx

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Submitted date:
04/26/2024

Accepted date:
05/25/2024

Publication date:
08/02/2024

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