Autopsy and Case Reports
https://app.periodikos.com.br/journal/autopsy/article/doi/10.4322/acr.2024.506
Autopsy and Case Reports
Clinical Case Report and Review

Traveling together! - Intrathymic thyroid tissue in a patient with Graves’ disease

Hugh Ellis McCormick; Sidrah Khawar; Ameer Hamza

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Abstract

Ectopic thyroid tissue is rare in the general population and more prevalent in people who have existing thyroid disease. Common anatomical sites of ectopic thyroid tissue include the lateral cervical region, thyroglossal duct, mediastinum, lingual, sublingual, and submandibular region. Intrathymic ectopic thyroid tissue is exceedingly rare. The purpose of this report is to describe one such case in a 52-year-old African-American female with Graves’ disease. The patient presented for a physical exam and follow-up. During the exam, an incidental mediastinal mass was discovered, which was evaluated by imaging studies and subsequently was resected. Histologically, the mass was composed of variable-sized thyroid follicles lined by a monolayer of cuboidal to columnar follicular epithelial cells and filled with eosinophilic colloid, surrounded by a rim of unremarkable compressed thymic tissue.

Keywords

Ectopic thyroid, Intrathymic thyroid, Thoracic intrathymic thyroid, Benign thymic nodule, Mediastinal mass, Graves’ disease

References

1 Santangelo G, Pellino G, De Falco N, et al. Prevalence, diagnosis and management of ectopic thyroid glands. Int J Surg. 2016;28(Suppl 1):S1-6. http://doi.org/10.1016/j.ijsu.2015.12.043. PMid:26708843.

2 Spinner RJ, Moore KL, Gottfried MR, Lowe JE, Sabiston DC Jr. Thoracic intrathymic thyroid. Ann Surg. 1994;220(1):91-6. http://doi.org/10.1097/00000658-199407000-00013. PMid:8024364.

3 Rosen RD, Sapra A. Embryology, Thyroid. In: StatPearls Publishing. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 [cited 2023 Aug 6]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK551611/

4 Wee T, Lee AF, Nadel H, Bray H. The paediatric thymus: recognising normal and ectopic thymic tissue. Clin Radiol. 2021;76(7):477-87. http://doi.org/10.1016/j.crad.2021.02.017. PMid:33762135.

5 Hwang I, Lee SK, Cho KJ, Kim KR. Heterotopic intrathymic thyroid tissue. Pathol Int. 2006;56(10):629-32. http://doi.org/10.1111/j.1440-1827.2006.02019.x. PMid:16984621.

6 Tang AT, Johnson MJ, Addis B, Weeden DF. Thoracic intrathymic thyroid and cervical goiter: single-stage resection. Ann Thorac Surg. 2002;74(2):578-9. http://doi.org/10.1016/S0003-4975(02)03557-9. PMid:12173852.

7 Frates MC, Benson CB, Dorfman DM, Cibas ES, Huang SA. Ectopic intrathyroidal thymic tissue mimicking thyroid nodules in children. J Ultrasound Med. 2018;37(3):783-91. http://doi.org/10.1002/jum.14360. PMid:28850707.

8 Nakaya M, Ito A, Mori A, et al. Surgical treatment of substernal goiter: an analysis of 44 cases. Auris Nasus Larynx. 2017;44(1):111-5. http://doi.org/10.1016/j.anl.2016.02.016. PMid:26995097.

9 Barker TA, Daultrey CR, Trotter SE, Kalkat M. Intrathymic primary intrathoracic goiter in a patient with breast malignancy. Ann Thorac Surg. 2012;93(2):e35-6. http://doi.org/10.1016/j.athoracsur.2011.09.052. PMid:22269766.

10 Jakibchuk K, Ali S, Samantray J. Recurrence of Graves’ disease in ectopic thyroid tissue. BMJ Case Rep. 2018;2018:bcr2017221566. http://doi.org/10.1136/bcr-2017-221566. PMid:29367360.
 


Submitted date:
11/01/2023

Accepted date:
05/14/2024

Publication date:
07/30/2024

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