Autopsy and Case Reports
https://app.periodikos.com.br/journal/autopsy/article/doi/10.4322/acr.2024.494
Autopsy and Case Reports
Short Communication

Giant intrapulmonary solitary fibrous tumor

Sheela Devi Chandakavadi Shivalingaiah; Deepika Gurumurthy; Gauri Dadich

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Abstract

Solitary fibrous tumor (SFT) is a soft tissue tumor of mesenchymal origin involving, most commonly, the pleura. Intrapulmonary SFT is a slow-growing tumor that rarely reaches giant forms. SFTs are asymptomatic and often randomly discovered by routine chest X-rays. The diagnosis requires histopathological and immunohistochemical (IHC) examinations. Most of the SFTs are benign and present an indolent course. Larger tumors are more likely to be malignant and consequently associated with a worse prognosis. Despite having histopathological criteria for malignancy, the behavior of SFTs is challenging to predict. We report a case of giant intrapulmonary SFT of intermediate risk.

Keywords

Solitary Fibrous Tumors, Lung, Immunohistochemistry

References

1 Palmieri G, Grassi C, Conti L, et al. Giant solitary fibrous tumor of the pelvis: a case report and review of literature. Int J Surg Case Rep. 2020;77S(Suppl):S52-6. http://doi.org/10.1016/j.ijscr.2020.09.058. PMid:32972891.

2 Zhou S, Zhan R, Qiao Z, Wu J. Giant solitary fibrous tumor: a clinically silent tumor. Asian J Surg. 2021;44(8):1085-6. http://doi.org/10.1016/j.asjsur.2021.05.018. PMid:34119388.

3 Hohenforst-Schmidt W, Grapatsas K, Dahm M, et al. Solitary fibrous tumor: a center’s experience and an overview of the symptomatology, the diagnostic and therapeutic procedures of this rare tumor. Respir Med Case Rep. 2017;21:99-104. http://doi.org/10.1016/j.rmcr.2017.04.007. PMid:28458994.

4 Guo J, Chu X, Sun YE, Zhang L, Zhou N. Giant solitary fibrous tumor of the pleura: an analysis of five patients. World J Surg. 2010;34(11):2553-7. http://doi.org/10.1007/s00268-010-0715-x. PMid:20628740.

5 Perrotta F, Cerqua FS, Cammarata A, et al. Integrated therapeutic approach to giant solitary fibrous tumor of the pleura: report of a case and review of the literature. Open Med (Wars). 2016;11(1):220-5. http://doi.org/10.1515/med-2016-0042. PMid:28352798.

6 Barata M, Cabral D, Sequeira P, Couto C, Oliveira A, Rodrigues C. Solitary fibrous tumor of the pleura: a giant finding, a benign entity? Respir Med Case Rep. 2021;33:101411. http://doi.org/10.1016/j.rmcr.2021.101411. PMid:34401259.

7 Ershadi R, Rahim M, Abbasi M, Erfanian R. Giant solitary fibrous tumor of the pleura. J Surg Case Rep. 2018;2018(11):rjy270. http://doi.org/10.1093/jscr/rjy270. PMid:30397437.

8 Furukawa N, Hansky B, Niedermeyer J, Gummert J, Renner A. A silent gigantic solitary fibrous tumor of the pleura: case report. J Cardiothorac Surg. 2011;6(1):122. http://doi.org/10.1186/1749-8090-6-122. PMid:21958732.

9 Kanamori Y, Hashizume K, Sugiyama M, et al. Intrapulmonary solitary fibrous tumor in an eight-year-old male. Pediatr Pulmonol. 2005;40(3):261-4. http://doi.org/10.1002/ppul.20250. PMid:15957162.

10 Ronchi A, Cozzolino I, Zito Marino F, et al. Extrapleural solitary fibrous tumor: a distinct entity from pleural solitary fibrous tumor. An update on clinical, molecular and diagnostic features. Ann Diagn Pathol. 2018;34:142-50. http://doi.org/10.1016/j.anndiagpath.2018.01.004. PMid:29660566.

11 Rao N, Colby TV, Falconieri G, Cohen H, Moran CA, Suster S. Intrapulmonary solitary fibrous tumors: clinicopathologic and immunohistochemical study of 24 cases. Am J Surg Pathol. 2013;37(2):155-66. http://doi.org/10.1097/PAS.0b013e31826a92f5. PMid:23108019.

12 Lin X, Xiang Y, Shi H, Zhang F. Primary intrapulmonary solitary fibrous tumours. Oncol Lett. 2018;15(3):3653-61. PMid:29467886.

13 England DM, Hochholzer L, McCarthy MJ. Localized benign and malignant fibrous tumors of the pleura. A clinicopathologic review of 223 cases. Am J Surg Pathol. 1989;13(8):640-58. http://doi.org/10.1097/00000478-198908000-00003. PMid:2665534.

14 Woodard GA, Fels Elliott DR, Yap A, et al. Resectability, recurrence, and risk stratification of giant solitary fibrous tumors in the thoracic cavity. Ann Surg Oncol. 2021;28(9):4953-9. http://doi.org/10.1245/s10434-021-09757-7. PMid:33728541.

15 Diebold M, Soltermann A, Hottinger S, et al. Prognostic value of MIB-1 proliferation index in solitary fibrous tumors of the pleura implemented in a new score – a multicenter study. Respir Res. 2017;18(1):210. http://doi.org/10.1186/s12931-017-0693-8. PMid:29246159.

16 Geramizadeh B, Marzban M, Churg A. Role of immunohistochemistry in the diagnosis of solitary fibrous tumor, a review. Iran J Pathol. 2016;11(3):195-203. PMid:27799967.

17 Inoue T, Owada Y, Watanabe Y, et al. Recurrent intrapulmonary solitary fibrous tumor with malignant transformation. Ann Thorac Surg. 2016;102(1):e43-5. http://doi.org/10.1016/j.athoracsur.2015.12.022. PMid:27343529.

18 Tariq MU, Din NU, Abdul-Ghafar J, Park YK. The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior. Diagn Pathol. 2021;16(1):32. http://doi.org/10.1186/s13000-021-01095-2. PMid:33879215.
 


Submitted date:
12/07/2023

Accepted date:
04/22/2024

Publication date:
06/21/2024

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