Autopsy and Case Reports
https://app.periodikos.com.br/journal/autopsy/article/doi/10.4322/acr.2024.481
Autopsy and Case Reports
Clinical Case Report

Hyaline cartilage at the portal plate and gallbladder in biliary atresia

Sangamitra Rajasekaran; Hari Neupane; Monika Bawa; Uma Nahar Saikia; Sadhna Lal; Suvradeep Mitra

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Abstract

Biliary atresia (BA) is a fibro-obliterative cholestatic disease of infancy. The presence of cartilage in the resected tissue is an uncommon finding.

We documented the presence of both mature and immature hyaline cartilage in the portal plate and the wall of the gallbladder in a 2-month-old girl infant with BA who had undergone Kasai portoenterostomy.

The presence of cartilage could be part of a heterotopia or an uncommon connective tissue metaplasia. The presence of immature cartilage with the merging of the perichondrium with the soft tissue highlights a metaplastic etiology in the index case.

Keywords

Biliary atresia, Hyaline cartilage, Portal plate, Gallbladder, Metaplasia

References

1 Ayyanar P, Mahalik SK, Pati AB, Mitra S. The presence of pericholedochal hyaline cartilage in biliary atresia: a report and a review. Fetal Pediatr Pathol. 2020;39(2):156-62. http://dx.doi.org/10.1080/15513815.2019.1639091. PMid:31314631.

2 Stahlschmidt J, Stringer MD, Wyatt J, Davison S, Rajwal S, McClean P. Histologic oddities at the porta hepatis in biliary atresia. J Pediatr Surg. 2008;43(7):1328-32. http://dx.doi.org/10.1016/j.jpedsurg.2007.09.017. PMid:18639690.

3 Hassab MH, Baez-Giangreco A, Afzal M, Shadi SM, Al Olayet YF. Extrahepatic biliary atresia with hyaline cartilage and multiple congenital anomalies: a case report. Saudi J Gastroenterol. 1996;2(3):156-9. PMid:19864825.

4 Mirkin LD, Knisely AS. Hyaline cartilage at porta hepatis in extrahepatic biliary atresia. Pediatr Pathol Lab Med. 1997;17(4):587-91. http://dx.doi.org/10.1080/15513819709168735. PMid:9211551.

5 Kashiwagi Y, Kawashima H, Ioi H, et al. Biliary atresia with cartilage formation. Pediatr Int. 2007;49(5):683-5. http://dx.doi.org/10.1111/j.1442-200X.2007.02434.x. PMid:17875102.

6 Altamirano E, Drut R. Extrahepatic biliary atresia with cartilaginous metaplasia in the gallbladder remnants. J Clin Pathol. 2008;61(8):965-6. http://dx.doi.org/10.1136/jcp.2006.045831. PMid:17307867.

7 Vij M, Bachina P, Safwan M. Portal plate with hyaline cartilage in biliary atresia. Indian J Pediatr. 2016;83(2):185-6. http://dx.doi.org/10.1007/s12098-015-1805-4. PMid:26051879.

8 Gupta RK, Batra VV, Sengar M, Sakhuja P, Rooge SN. Biliary atresia with hyaline cartilage at the porta hepatis. Ann Pediatr Surg. 2016;12(3):122-5. http://dx.doi.org/10.1097/01.XPS.0000481345.13724.a4.

9 Elhence P, Sinha A. Hyaline cartilage at porta hepatis in extrahepatic biliary atresia: metaplasia or choristoma. Sudan J Paediatr. 2020;20(1):73-6. http://dx.doi.org/10.24911/SJP.106-1518980907. PMid:32528205.

10 Hartley JL, Davenport M, Kelly DA. Biliary atresia. Lancet. 2009;374(9702):1704-13. http://dx.doi.org/10.1016/S0140-6736(09)60946-6. PMid:19914515.

11 Mitra S, Ayyanar P, Mahalik SK, Patra S, Purkait S, Satapathy AK. Diminution of the primary cilia from the intrahepatic cholangiocytes in a pediatric choledochal cyst. Appl Immunohistochem Mol Morphol. 2021;29(10):773-80. http://dx.doi.org/10.1097/PAI.0000000000000953. PMid:34081636.

12 Zhao D, Long XD, Xia Q. Recent advances in etiology of biliary atresia. Clin Pediatr. 2015;54(8):723-31. http://dx.doi.org/10.1177/0009922814548841. PMid:25187275.
 


Submitted date:
01/09/2024

Accepted date:
02/28/2024

Publication date:
04/04/2024

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