Autopsy and Case Reports
https://app.periodikos.com.br/journal/autopsy/article/doi/10.4322/acr.2024.478
Autopsy and Case Reports
Clinical Case Report

Exploring the unusual: a testosterone-secreting ovarian tumor

Harpreet Kaur; Neha Singh; Sushma Bharti; Gurwinder Kaur

http://dx.doi.org/10.4322/acr.2024.478 Autops Case Rep, vol.14, e2024478, 2024
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Abstract

Ovarian steroid cell tumors are rare, representing less than 0.1% of all ovarian neoplasms. Among the myriad causes of hirsutism, ovarian tumors account for 1% of the reported cases. We present the case of a 49-year-old parous postmenopausal woman who sought medical attention for hirsutism for 2 years. This case illustrates the unusual and interesting connection between rare ovarian pathology and the clinical manifestation of hirsutism in a postmenopausal patient. Her ultrasonography and MRI showed a right adnexal mass of solid-cystic consistency with thin septations. Her laboratory workup revealed high levels of total testosterone of 256 ng/ml (8.4-48.1ng/ml) and free testosterone of 7.36 pg/ml (0.2-4.1 pg/ml), while DHEAS - 234 µg/dl (35.4-256 µg/dl) and CA125 - 15.8U/L (0.0-35 U/L) were in the normal range. She underwent exploratory laparotomy with a total abdominal hysterectomy and oophorectomy. Histopathological examination and immunohistochemistry conclusively established the presence of a steroid cell tumor, specifically classified as "Not Otherwise Specified"(NOS), in the right ovary.

Keywords

Ovarian neoplasm, Sex Cord-Gonadal Stromal Tumours, Hirsutism, Postmenopause.

References

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Submitted date:
12/21/2023

Accepted date:
02/12/2024

Publication date:
02/26/2024

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