Alcoholic foamy degeneration: an unusual presentation of the alcoholic liver disease diagnosed on autopsy

Rashmi Joshi; Mayur Parkhi; Anjali Gupta; Terence Susngi; Ashwani Kumar; Deba Prasad Dhibar; Suvradeep Mitra

doi:10.4322/acr.2023.446

Autopsy Case Report

Alcoholic foamy degeneration: an unusual presentation of the alcoholic liver disease diagnosed on autopsy

Rashmi Joshi; Mayur Parkhi; Anjali Gupta; Terence Susngi; Ashwani Kumar; Deba Prasad Dhibar; Suvradeep Mitra

http://dx.doi.org/10.4322/acr.2023.446 Autops Case Rep, vol.13, e2023446, 2023

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Abstract

Alcoholic foamy degeneration (AFD) is an uncommon presentation of alcoholic liver disease (ALD) with characteristic histologic findings of foamy-looking hepatocytes due to the presence of abundant microvesicles of fat within the cytoplasm predominantly in perivenular and midzonal regions without inflammation and fibrosis. It is underdiagnosed as the patients quickly recover after alcoholic abstinence and are rarely caught on biopsies. AFD has better prognosis than alcoholic hepatitis, and the injury mechanism is different, warranting a different diagnosis. We present an uncommon case of AFD incidentally diagnosed during autopsy in a chronic alcoholic and diabetic man.

Keywords

Liver Diseases, Alcoholic, Pancreatitis, Acute Necrotizing, Autopsy

References

1 Uchida T, Kao H, Quispe-Sjogren M, Peters RL. Alcoholic foamy degeneration--a pattern of acute alcoholic injury of the liver. Gastroenterology. 1983;84(4):683-92. http://dx.doi.org/10.1016/0016-5085(83)90131-2. PMid:6825980.

2 Montull S, Parés A, Bruguera M, Caballería J, Uchida T, Rodés J. Alcoholic foamy degeneration in Spain. Prevalence and clinico-pathological features. Liver. 1989;9(2):79-85. http://dx.doi.org/10.1111/j.1600-0676.1989.tb00383.x. PMid:2709953.

3 Roth N, Kanel G, Kaplowitz N. Alcoholic foamy degeneration and alcoholic fatty liver with jaundice: often overlooked causes of jaundice and hepatic decompensation that can mimic alcoholic hepatitis. Clin Liver Dis. 2015;6(6):145-8. http://dx.doi.org/10.1002/cld.520. PMid:31041013.

4 Ruiz P, Michelena J, Altamirano J, et al. Hepatic hemodynamics and transient elastography in alcoholic foamy degeneration: report of 2 cases. Ann Hepatol. 2012;11(3):399-403. http://dx.doi.org/10.1016/S1665-2681(19)30938-X. PMid:22481461.

5 Suri S, Mitros FA, Ahluwalia JP. Case report: alcoholic foamy degeneration and a markedly elevated GGT: a case report and literature review. Dig Dis Sci. 2003;48(6):1142-6. http://dx.doi.org/10.1023/A:1023781132498. PMid:12822877.

6 Kanel GC, Korula J. Atlas of liver pathology. London: Elsevier Health Sciences; 2010.

Submitted date:
06/19/2023

Accepted date:
08/14/2023

Publication date:
10/11/2023

Alcoholic foamy degeneration: an unusual presentation of the alcoholic liver disease diagnosed on autopsy

Rashmi Joshi; Mayur Parkhi; Anjali Gupta; Terence Susngi; Ashwani Kumar; Deba Prasad Dhibar; Suvradeep Mitra

Abstract

Keywords

References

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Autops Case Rep