Embryonal rhabdomyosarcoma of the uterine cervix in an adult female
Toyaja Jadhav; Manoj Gopal Madakshira; Sushil Garud
Abstract
Keywords
References
1 Jayi S, Bouguern H, Fdili FZ, et al. Embryonal rhabdomyosarcoma of the cervix presenting as a cervical polyp in a 16-year-old adolescent: A case report. J Med Case Rep. 2014;8(1):241.
2 Shim AR, Lee M, Paek JH, Kim MJ, Kim SW. A case of embryonal rhabdomyosarcoma of the uterine cervix in a middle-aged woman. Korean Journal of Obstetrics & Gynecology. 2011;54(11):707.
3 Gomes AR, Leite PB, Rocha JS, et al. Embryonal rhabdomyosarcoma of the uterine cervix: a rare case report. Int J Reprod Contracept Obstet Gynecol. 2016;6(1):309.
4 Mousavi A, Akhavan S. Sarcoma botryoides (embryonal rhabdomyosarcoma) of the uterine cervix in sisters. J Gynecol Oncol. 2010;21(4):273-5.
5 Horn RC Jr, Enterline HT. Rhabdomyosarcoma: a clinicopathological study and classification of 39 cases. Cancer. 1958;11(1):181-99.
6 Rudzinski ER, Anderson JR, Hawkins DS, Skapek SX, Parham DM, Teot LA. The world health organization classification of skeletal muscle tumors in pediatric rhabdomyosarcoma a report from the children’s oncology group. Arch Pathol Lab Med. 2015;139(10):1281-7.
7 Buruiana FE, Gupta B, Singh K. Rhabdomyosarcoma of the cervix in teenagers - Is fertility preservation a feasible option? Gynecol Oncol Rep. 2020;34:100677.
8 Qualman S, Lynch J, Bridge J, et al. Prevalence and clinical impact of anaplasia in childhood rhabdomyosarcoma: a report from the Soft Tissue Sarcoma Committee of the Children’s Oncology Group. Cancer. 2008;113(11):3242-7.
9 Shenoy A, Alvarez E, Chi YY, et al. The prognostic significance of anaplasia in childhood rhabdomyosarcoma: a report from the Children’s Oncology Group. Eur J Cancer. 2021;143:127-33.
10 Cramer SL, Miller AL, Pressey JG, et al. Pediatric anaplastic embryonal rhabdomyosarcoma: targeted therapy guided by genetic analysis and a patient-derived xenograft study. Front Oncol. 2018;7(JAN):327.
11 Kaseb H, Kuhn J, Babiker HM. StatPearls. Treasure Island (FL): StatPearls Publishing; 2022.
12 Connor EV, Disilvestro PA. Obstetrics and gynaecology cases-reviews diagnosis and management of embryonal rhabdomyosarcoma in a woman with prolapsing cervical mass. Obstet Gynecol Cases Rev. 2015;2(4):4.
13 Khosla D, Gupta R, Srinivasan R, Patel FD, Rajwanshi A. Sarcomas of uterine cervix: clinicopathological features, treatment, and outcome. Int J Gynecol Cancer. 2012;22(6):1026-30.
14 Dehner LP, Jarzembowski JA, Hill DA. Embryonal rhabdomyosarcoma of the uterine cervix: a report of 14 cases and a discussion of its unusual clinicopathological associations. Mod Pathol. 2012;25(4):602-14.
15 Bahall V, de Barry L, Sankar S. A rare case of embryonal rhabdomyosarcoma of the uterine cervix. Case Rep Pathol. 2022;2022:8459566.
16 Apellaniz-Ruiz M, McCluggage WG, Foulkes WD. DICER1‐associated embryonal rhabdomyosarcoma and adenosarcoma of the gynecologic tract: pathology, molecular genetics, and indications for molecular testing. Genes Chromosomes Cancer. 2021;60(3):217-33.
17 Clay MR. Soft tissue; Skeletal muscle Rhabdomyosarcoma; Embryonal rhabdomyosarcoma. [place unknown]; 2022 [cited 2022 Oct 22]. Available from:
18 Ibrahim U, Saqib A, Mohammad F, et al. Embryonal rhabdomyosarcoma of the cervix: a rare disease at an uncommon age. Cureus. 2017;9(11):e1864.
19 Meng L, Zhang Q, Han Q, Sun X, Liu Y, Huang X. Embryonic cervical rhabdomyosarcoma complicated with uterine inversion with cerebral venous sinus thrombosis as the first symptom: a case report and literature review. J Int Med Res. 2021;49(8):3000605211031776.
20 Gibson MC, Nasiri N. Rhabdomyoma. Vienna: WikiDoc; 2019 [cited 2023 Jan 4]. Available from:
21 Elliott G, Reynolds H, Fidler H. Pseudo-sarcoma botryoides of cervix and vagina in pregnancy*. J Obstet Gynaecol Br Commonw. 1967;74(5):728-33.
22 Heller A, Ukazu A, Wang Q. Pseudosarcomatous vaginal polyp: a benign mimic of malignancy. Int J Surg Pathol. 2016;1(2):1-2.
23 Lindberg M, Lucas D, Gardner JM, Cassarino D, Stallings-Archer K. Diagnostic pathology: soft tissue tumours. 2nd ed. Local: Elsevier; 2016. p. 372-7: Embryonal Rhabdomyosarcoma.
24 Narayana Kurup JK, Kamble VC, Acharya AM, Bhat AK. Massive embryonal rhabdomyosarcoma of the hand in an infant with metastasis at birth: management dilemma. Hand (N Y). 2017;12(5):NP109-12.
25 Norris HJ, Taylor HB. Polyps of the vagina. A benign lesion resembling sarcoma botryoides. Cancer. 1966;19(2):227-32.
26 Health Jade. Rhabdomyoma [place unknown]; c2019 [cited 2023 Jan 4]. Available from:
27 Song JS, Song DE, Kim KR, Ro JY. Cellular pseudosarcomatous fibroepithelial stromal polyp of the vagina during pregnancy: a lesion that is overdiagnosed as a malignant tumor. Korean J Pathol. 2012;46(5):494-8.
28 Wyant T, Alteri R, Kalidas M, et al. Rhabdomyosarcoma causes, risk factors, and prevention[place unknown]; 2018 [cited 2022 Oct 22]. Available from:
29 National Cancer Institute. Childhood Rhabdomyosarcoma Treatment (PDQ®)-Patient Version. [place unknown]; 2022 [cited 2022 Oct 22]. Available from:
30 Wang X, Feng J, Li Z, Zhang X, Chen J, Feng G. Characteristics and prognosis of embryonal rhabdomyosarcoma in children and adolescents: an analysis of 464 cases from the SEER database. Pediatr Investig. 2020;4(4):242-9.
31 Caruso RA, Napoli P, Villari D, Starrantino M. Anaplastic (pleomorphic) subtype embryonal rhabdomyosarcoma of the cervix. Arch Gynecol Obstet. 2004;270(4):278-80.
32 Chapell DB. Uterus: other mesenchymal tumors - Undifferentiated uterine sarcoma. [place unknown]; 2021 [cited 2022 Oct 22]. Available from:
33 Han L, Benett J. Uterus Stromal tumors: high grade endometrial stromal sarcoma. [place unknown]; 2021 [cited 2022 Oct 22]. Available from:
34 Rawish KR, Fadare O. Dedifferentiated leiomyosarcoma of the uterus with heterologous elements: a potential diagnostic pitfall. Case Rep Obstet Gynecol. 2012;2012:534634.
35 Özen ÖI, Ayhan A. Uterus: mixed epithelial and mesenchymal tumors - Müllerian adenosarcoma. [place unknown]; 2021 [cited 2022 Oct 22]. Available from:
36 Iihara K, Hirano K, Fujioka Y, Sakamoto A. Leiomyosarcoma with dedifferentiation in a premenopausal patient discovered after uterine artery embolization. Pathol Int. 2007;57(10):681-7.
37 Nicolas MM, Tamboli P, Gomez JA, Czerniak BA. Pleomorphic and dedifferentiated leiomyosarcoma: clinicopathologic and immunohistochemical study of 41 cases. Hum Pathol. 2010;41(5):663-71.
38 Shankar V. Soft tissue: smooth muscle - Leiomyosarcoma; Leiomyosarcoma-general[place unknown]; 2022 [cited 2022 Oct 22]. Available from:
39 Allanson ER, Cummings M, Kuchel A, Wastney T, Nicklin J. Undifferentiated uterine sarcoma: a multidisciplinary challenge. Int J Gynecol Cancer. 2022;32(2):198-202.
40 Zhang Y, Chen C, Ren M, Cong X, Li Z, Yang L. Treatment of uterine high-grade endometrial stromal sarcoma with apatinib combined with chemotherapy: a case report. Medicine (Baltimore). 2019;98(13):e15050.
41 Shi Y, Liu Z, Peng Z, Liu H, Yang K, Yao X. The diagnosis and treatment of Mullerian adenosarcoma of the uterus. Aust N Z J Obstet Gynaecol. 2008;48(6):596-600.
42 Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP. Uterine Leiomyosarcoma. Oncol Res Treat. 2018;41(11):680-6.
43 Chen J, Liu X, Lan J, et al. Rhabdomyosarcoma in adults: case series and literature review. Int J Womens Health. 2022;14:405-14.
44 American Cancer Society. Uterine sarcoma early detection, diagnosis, and staging. [place unknown]; 2022 [cited 2022 Oct 22]. Available from:
45 Varghese M, Bruland O, Wiedswang AM, et al. Metastatic mesenteric dedifferentiated leiomyosarcoma: a case report and a review of literature. Clin Sarcoma Res. 2016;6(1):2.
46 Seagle BLL, Kanis M, Strohl AE, Shahabi S. Survival of women with Mullerian adenosarcoma: a national cancer data base study. Gynecol Oncol. 2016;143(3):636-41.
47 Zhang YY, Li Y, Qin M, Cai Y, Jin Y, Pan LY. High-grade endometrial stromal sarcoma: a retrospective study of factors influencing prognosis. Cancer Manag Res. 2019;11:831-7.
48 Shankar V. Soft tissue; Skeletal muscle - Rhabdomyoma; Adult type rhabdomyoma. [place unknown]; 2021 [cited 2022 Oct 22]. Available from:
49 Shankar V. Soft tissue: Skeletal muscle - Rhabdomyoma; Genital type rhabdomyoma. [place unknown]; 2021 [cited 2022 Oct 22]. Available from:
50 Neha B, Manjunath AP, Girija S, Pratap K. Botryoid Rhabdomyosarcoma of the cervix: case report with review of the literature. Sultan Qaboos Univ Med J. 2015;15(3):e433-7.
Submitted date:
10/22/2022
Accepted date:
01/04/2023
Publication date:
01/27/2023
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