Co-occurrence of myeloid neoplasm and plasma cell neoplasm

Husam Jum’ah; Yan Wang; Salman Ayub

doi:10.4322/acr.2021.393

Clinical Case Report

Co-occurrence of myeloid neoplasm and plasma cell neoplasm

Husam Jum’ah; Yan Wang; Salman Ayub

http://dx.doi.org/10.4322/acr.2021.393 Autops Case Rep, vol.12, e2021393, 2022

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Abstract

Co-occurrence of myelodysplastic syndrome (MDS) and plasma cell neoplasm in patients with no history of chemo and/or radiotherapy is rarely reported. Herein, we report a case of a female in her seventieth decade of life who was referred to the hospital for pancytopenia. The patient was asymptomatic and was doing well overall. Serum protein electrophoresis was remarkable for a lambda-restricted monoclonal protein (IgG) estimated at 1.8g/dL. Immunoglobulin G serum level was also elevated, and serum Kappa/Lambda free light chain ratio was decreased. At that time, a bone marrow biopsy showed myelodysplastic syndrome with excess blasts-2 (MDS-EB2) and a monoclonal plasma cell proliferation. Some studies have shown that patients with plasma cell neoplasm could be associated with an increased risk of developing MDS compared to the general population. Based on reviewing the literature, to our knowledge, the pathological mechanism of the co-occurrence of both diseases is not yet clear.

Keywords

Myelodysplastic Syndromes, Monoclonal Gammopathy of Undetermined Significance, Smoldering Multiple Myeloma, Bone Marrow, Pancytopenia

References

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Submitted date:
02/26/2022

Accepted date:
07/06/2022

Publication date:
07/21/2022

Co-occurrence of myeloid neoplasm and plasma cell neoplasm

Husam Jum’ah; Yan Wang; Salman Ayub

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