Congenital Rubella Syndrome as a possible cause for persistent thrombocytopenia in early infancy: The Forgotten Culprit

Jogender Kumar; Venkataseshan Sundaram; Kirti Gupta; Anmol Bhatia; Gurwinder Kaur; Sourabh Dutta

doi:10.4322/acr.2021.386

Autopsy Case Report

Congenital Rubella Syndrome as a possible cause for persistent thrombocytopenia in early infancy: The Forgotten Culprit

Jogender Kumar; Venkataseshan Sundaram; Kirti Gupta; Anmol Bhatia; Gurwinder Kaur; Sourabh Dutta

http://dx.doi.org/10.4322/acr.2021.386 Autops Case Rep, vol.12, e2021386, 2021

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Abstract

We present a case of a late preterm intrauterine growth-restricted neonate with isolated and persistent severe thrombocytopenia. At birth, the neonate did not have a complete clinical spectrum of congenital rubella syndrome (CRS) but later developed peculiar findings that helped clinch the diagnosis. The neonate also had interstitial pneumonia and died secondary to superimposed acute viral infection leading to acute respiratory distress syndrome. The serology was positive for IgM antibodies against the rubella virus. The constellation of clinical manifestations of congenital rubella in the presence of positive IgM antibody against rubella and consistent histopathology confirmed the diagnosis of CRS.

Keywords

Rubella Syndrome, Congenital, Thrombocytopenia, Pathology, Neuropathology, Autopsy

References

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3 Dewan P, Gupta P. Burden of Congenital Rubella Syndrome (CRS) in India: a systematic review. Indian Pediatr. 2012;49(5):377-99. http://dx.doi.org/10.1007/s13312-012-0087-4. PMid:22700664.

4 Sharma H, Chowdhari S, Raina TR, Bhardwaj S, Namjoshi G, Parekh S. Sero-surveillance to assess immunity to rubella and assessment of immunogenicity and safety of a single dose of rubella vaccine in school girls. Indian J Community Med. 2010;35(1):134-7. http://dx.doi.org/10.4103/0970-0218.62575. PMid:20606938.

5 Lanzieri T, Redd S, Abernathy E, Icenogle J. Congenital Rubella Syndrome. In: Roush SW, Baldy LM, Hall MAK. Manual for the surveillance of vaccine-preventable diseases. USA: Centers for Disease Control and Prevention; 2014 [cited 2022 Feb 14]. Available from: https://www.cdc.gov/vaccines/pubs/surv-manual/chpt15-crs.html

Submitted date:
02/03/2022

Accepted date:
05/23/2022

Publication date:
06/06/2022

Congenital Rubella Syndrome as a possible cause for persistent thrombocytopenia in early infancy: The Forgotten Culprit

Jogender Kumar; Venkataseshan Sundaram; Kirti Gupta; Anmol Bhatia; Gurwinder Kaur; Sourabh Dutta

Abstract

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Autops Case Rep