Autopsy and Case Reports
https://app.periodikos.com.br/journal/autopsy/article/doi/10.4322/acr.2020.225
Autopsy and Case Reports
Autopsy Case Report and Review

Fatal tumor lysis syndrome in a patient with metastatic gastric adenocarcinoma

Robin Moiseff; Cameron Felty; Xiaoying Liu

Downloads: 9
Views: 1636

Abstract

ABSTRACT: Tumor lysis syndrome is a well-characterized and potentially deadly complication of spontaneous or treatment-related tumor destruction, and it is most commonly associated with hematologic malignancies. Our case illustrates a rare example of fatal tumor lysis syndrome in the setting of metastatic gastric adenocarcinoma treated with radiation therapy. This case highlights the critical importance of identifying patients with solid organ malignancies at risk for tumor lysis syndrome and of early recognition and treatment of this syndrome.

Keywords

Stomach, Stomach Neoplasms, Tumor lysis Syndrome

References

1 McBride A, Westervelt P. Recognizing and managing the expanded risk of tumor lysis syndrome in hematologic and solid malignancies. J Hematol Oncol. 2012;5(1):75. http://dx.doi.org/10.1186/1756-8722-5-75. PMid:23237230.

2 Baeksgaard L, Sørensen JB. Acute tumor lysis syndrome in solid tumors-A case report and review of the literature. Cancer Chemother Pharmacol. 2003;51(3):187-92. http://dx.doi.org/10.1007/s00280-002-0556-x. PMid:12655435.

3 Howard SC, Jones DP, Pui CH. The tumor lysis syndrome. N Engl J Med. 2011;364(19):1844-54. http://dx.doi.org/10.1056/NEJMra0904569. PMid:21561350.

4 Howard SC, Trifilio S, Gregory TK et al. Tumor lysis syndrome in the era of novel and targeted agents in patients with hematologic malignancies: a systematic review. Ann Hematol. 2016; 95:563. https://doi.org/10.1007/s00277-015-2585-7.

5 Zafrani L, Canet E, Darmon M. Understanding tumor lysis syndrome. Intensive Care Med. 2019;45(11):1608-11. http://dx.doi.org/10.1007/s00134-019-05768-x. PMid:31520104.

6 Cairo MS, Bishop M. Tumour lysis syndrome: new therapeutic strategies and classification. Br J Haematol. 2004;127(1):3-11. http://dx.doi.org/10.1111/j.1365-2141.2004.05094.x. PMid:15384972.

7 Mirrakhimov AE, Ali AM, Khan M, Barbaryan A. Tumor lysis syndrome in solid tumors: An up to date review of the literature. Rare Tumors. 2014;6(2):5389. http://dx.doi.org/10.4081/rt.2014.5389. PMid:25002953.

8 Vodopivec DM, Rubio JE, Fornoni A, Lenz O. An unusual presentation of tumor lysis syndrome in a patient with advanced gastric adenocarcinoma: case report and literature review. Case Rep Med. 2012;2012:468452. http://dx.doi.org/10.1155/2012/468452. PMid:22685470.

9 Woo IS, Kim JS, Park MJ, et al. Spontaneous acute tumor lysis syndrome with advanced gastric cancer. J Korean Med Sci. 2001;16(1):115-8. http://dx.doi.org/10.3346/jkms.2001.16.1.115. PMid:11289389.

10 Han HS, Park SR, Kim SY, et al. Tumor lysis syndrome after capecitabine plus cisplatin treatment in advanced gastric cancer. J Clin Oncol. 2008;26(6):1006-8. http://dx.doi.org/10.1200/JCO.2007.14.7231. PMid:18281674.

11 Kobayashi T, Kuwai T, Yamamoto S, et al. Acute tumor lysis syndrome in the setting of advanced gastric cancer. Nihon Shokakibyo Gakkai Zasshi. 2012;109:1372-8. http://dx.doi.org/10.11405/nisshoshi.109.1372

12 Goyal H, Sawhney H, Bekara S, Singla U. Spontaneous acute tumour lysis syndrome in gastric adenocarcinoma: a case report and literature review. J Gastrointest Cancer. 2014;45(1, Suppl):208-11. http://dx.doi.org/10.1007/s12029-014-9632-9. PMid:24952154.

13 Caravaca-Fontán F, Martínez-Sáez O, Pampa-Saico S, Olmedo ME, Gomis A, Garrido P. Tumour lysis syndrome in solid tumors: clinical characteristics and prognosis. Med Clin (Barc). 2017;148(3):121-4. http://dx.doi.org/10.1016/j.medcle.2016.10.048. PMid:27993406.

14 Salmón-González Z, Vieitez-Santiago M, Martino-González M, Hernández JL, Alonso-Gutierrez J. Spontaneous tumor lysis syndrome occurring in untreated gastric adenocarcinoma. QJM. 2019;112(1):39-40. http://dx.doi.org/10.1093/qjmed/hcy232. PMid:30304519.

15 Lingamaneni P, Desai MP, Mathew M, Moturi K, Krishna R, Gupta S. Tumor lysis syndrome in a patient with gastric adenocarcinoma. Am J Gastroenterol. 2019;114(1):S1492-3. http://dx.doi.org/10.14309/01.ajg.0000600340.90527.3a.

16 Chen K-B, Xi W-J, Huang Y, et al. Spontaneous Tumor Lysis Syndrome in a patient with advanced gastric adenocarcinoma. Transl Cancer Res. 2019;8(4):1647-52. http://dx.doi.org/10.21037/tcr.2019.07.53.
 


Submitted date:
05/14/2020

Accepted date:
07/29/2020

Publication date:
12/08/2020

5fcfc0150e882511034ac228 autopsy Articles
Links & Downloads

Autops Case Rep

Share this page
Page Sections