A pancreatic mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) (NET and undifferentiated carcinoma of the pancreas with osteoclast-like giant cells) with metastatic neuroendocrine component to the liver
Guofeng Gao; Amir Qorbani; Chihong Heidi Zhou
Abstract
Keywords
References
1 Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM, Matrisian LM. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res. 2014;74(11):2913-21.
2 Noone AM, Howlader N, Krapcho M, et al, editors. SEER cancer statistics review, 1975-2015 [Internet]. Bethesda: National Cancer Institute; 2015 [cited 2018 Apr 1]. Available from:
3 Kamisawa T, Wood LD, Itoi T, Takaori K. Pancreatic cancer. Lancet. 2016;388(10039):73-85.
4 Temesgen WM, Wachtel M, Dissanaike S. Osteoclastic giant cell tumor of the pancreas. Int J Surg Case Rep. 2014;5(4):175-9.
5 Sommers SC, Meissner WA. Unusual carcinomas of the pancreas. AMA Arch Pathol. 1954;58(2):101-11. PMid:13170907.
6 Klimstra DS, Kloppel G, La Rosa S, Rindi G. Classification of neuroendocrine neoplasms of the digestive system. In: WHO Classification of Tumours Editorial Board, editor. WHO classification of tumours: digestive system tumours. 5th ed. Lyon: IARC Press; 2019.
7 Luchini C, Pea A, Lionheart G, et al. Pancreatic undifferentiated carcinoma with osteoclast-like giant cells is genetically similar to, but clinically distinct from, conventional ductal adenocarcinoma. J Pathol. 2017;243(2):148-54.
8 Luchini C, Cros J, Pea A, et al. PD-1, PD-L1, and CD163 in pancreatic undifferentiated carcinoma with osteoclast-like giant cells: expression patterns and clinical implications. Hum Pathol. 2018;81:157-65.
9 Athanasios P, Alexandros P, Nicholas B, et al. Pleomorphic giant cell carcinoma of the pancreas with hepatic metastases: initially presenting as a benign serous cystadenoma: a case report and review of the literature. HPB Surg. 2010;2010:627360.
10 Menteş A, Yüce G. Osteoclast-type giant cell tumor of the pancreas associated with mucinous cystadenoma. Eur J Surg Oncol. 1993;19(1):84-6. PMid:8436245.
11 Rustagi T, Rampurwala M, Rai M, Golioto M. Recurrent acute pancreatitis and persistent hyperamylasemia as a presentation of pancreatic osteoclastic giant cell tumor: an unusual presentation of a rare tumor. Pancreatology. 2011;11(1):12-5.
12 Lukás Z, Dvorák K, Kroupová I, Valásková I, Habanec B. Immunohistochemical and genetic analysis of osteoclastic giant cell tumor of the pancreas. Pancreas. 2006;32(3):325-9.
13 Mullick SS, Mody DR. “Osteoclastic” giant cell carcinoma of the pancreas: report of a case with aspiration cytology. Acta Cytol. 1996;40(5):975-9.
14 Shi C, Klimstra DS. Pancreatic neuroendocrine tumors: pathologic and molecular characteristics. Semin Diagn Pathol. 2014;31(6):498-511.
15 Tang LH, Basturk O, Sue JJ, Klimstra DS. A practical approach to the classification of WHO Grade 3 (G3) Well-differentiated Neuroendocrine Tumor (WD-NET) and Poorly Differentiated Neuroendocrine Carcinoma (PD-NEC) of the Pancreas. Am J Surg Pathol. 2016;40(9):1192-202.
16 Waddell N, Pajic M, Patch AM, et al. Whole genomes redefine the mutational landscape of pancreatic cancer. Nature. 2015;518(7540):495-501.
17 Hijioka S, Hosoda W, Mizuno N, et al. Does the WHO 2010 classification of pancreatic neuroendocrine neoplasms accurately characterize pancreatic neuroendocrine carcinomas? J Gastroenterol. 2015;50(5):564-72.
18 Kimura T, Miyamoto H, Fukuya A, et al. Neuroendocrine carcinoma of the pancreas with similar genetic alterations to invasive ductal adenocarcinoma. Clin J Gastroenterol. 2016;9(4):261-5.
19 Muraki T, Reid MD, Basturk O, et al. undifferentiated carcinoma with osteoclastic giant cells of the pancreas: clinicopathologic analysis of 38 cases highlights a more protracted clinical course than currently appreciated. Am J Surg Pathol. 2016;40(9):1203-16.
20 Basturk O, Tang L, Hruban RH, et al. Poorly differentiated neuroendocrine carcinomas of the pancreas: a clinicopathologic analysis of 44 cases. Am J Surg Pathol. 2014;38(4):437-47.
21 Serafini S, Da Dalt G, Pozza G, et al. Collision of ductal adenocarcinoma and neuroendocrine tumor of the pancreas: a case report and review of the literature. World J Surg Oncol. 2017;15(1):93.
22 Wang Y, Gandhi S, Basu A, et al. Pancreatic collision tumor of ductal adenocarcinoma and neuroendocrine tumor. ACG Case Rep J. 2018;5(1):e39.
Submitted date:
02/01/2020
Accepted date:
06/20/2020
Publication date:
12/08/2020