Primary non-Hodgkin lymphoma of the bone (PLB) is a rare type of non-Hodgkin’s lymphoma (NHL) that affects the skeletal system with or without regional lymph node involvement. We present the case of a 74-year-old female patient with pain due to multifocal osteolytic lesions. The diagnosis of diffuse large B-cells (non-GCB) phenotype was made by clinical, laboratory, histopathological examination accompanied by an extensive immunohistochemical profile of one of the skeletal lesions.
LiuJ, FanS, WangJ, SongB. A rare case report of primary bone lymphoma and a brief review of the literature. OncoTargets Ther. 2016;9:4923-8. [https://doi.org/10.2147/OTT.S108000]. [PMID:27563248]
CarbonePP, KaplanHS, MusshoffK, SmithersDW, TubianaM. Report of the committee on Hodgkin’s disease staging classification. Cancer Res. 1971;31(11):1860-1. [PMID:5121694]
The International Non-Hodgkin’s Lymphoma Prognostic Factors Project. A predictive model for aggressive non-Hodgkin’s lymphomas. N Engl J Med. 1993;329(14):987-94. [https://doi.org/10.1056/NEJM199309303291402]. [PMID:8141877]
ZhouZ, SehnLH, RademakerAW, et al. An enhanced International Prognostic Index (NCCN-IPI) for patients with diffuse large B-cell lymphoma treated in the rituximab era. Blood. 2014;123(6):837-42. [https://doi.org/10.1182/blood-2013-09-524108]. [PMID:24264230]
Bruno VentreM, FerreriAJ, GospodarowiczM, et al. Clinical features, management, and prognosis of an international series of 161 patients with limited-stage diffuse large B-cell lymphoma of the bone (the IELSG-14 study). Oncologist. 2014;19(3):291-8. [https://doi.org/10.1634/theoncologist.2013-0249]. [PMID:24567283]
ChesonBD, FisherRI, BarringtonSF, et al. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol. 2014;32(27):3059-68. [https://doi.org/10.1200/JCO.2013.54.8800]. [PMID:25113753]
CıraklıA, ElliM, DabakN, Canbaz TosunF, DağdemirA, CıraklıS. Evaluation of primary bone lymphoma and the importance of positron emission tomography. Acta Orthop Traumatol Turc. 2014;48(3):371-8. [https://doi.org/10.3944/AOTT.2014.3014]. [PMID:24901932]
LiX, Xu-MonetteZY, YiS, et al. Primary bone lymphoma exhibits a favorable prognosis and distinct gene expression signatures resembling diffuse large B-cell lymphoma derived from centrocytes in the germinal center. Am J Surg Pathol. 2017;41(10):1309-21. [https://doi.org/10.1097/PAS.0000000000000923]. [PMID:28817403]
RamadanKM, ShenkierT, SehnLH, GascoyneRD, ConnorsJM. A clinicopathological retrospective study of 131 patients with primary bone lymphoma: a population-based study of successively treated cohorts from the British Columbia Cancer Agency. Ann Oncol. 2007;18(1):129-35. [https://doi.org/10.1093/annonc/mdl329]. [PMID:17018705]