Autopsy and Case Reports
https://app.periodikos.com.br/journal/autopsy/article/doi/10.4322/acr.2020.140
Autopsy and Case Reports
Article / Clinical Case Report

Generalized hereditary gingival fibromatosis in a child: clinical, histopathological and therapeutic aspects

John Lennon Silva Cunha; Maria Alice Carvalho da Cruz Ramos; Débora Menezes Regis; Celeste Sanchéz-Romero; Maria Eliane de Andrade; Bruno Torres Bezerra; Ricardo Luiz Cavalcanti de Albuquerque-Júnior

Downloads: 11
Views: 1643

Abstract

Hereditary gingival fibromatosis (HGF) is a rare genetic condition characterized by slow and progressive gingival enlargement. The gingival overgrowth often delays teeth eruption and may cause serious functional and aesthetic problems. We reported a case of a 10-year-old female child presenting a generalized gingival enlargement covering almost all the maxillary and mandibular teeth and resulted in problems for swallowing, speaking, and poor aesthetics. An incisional biopsy was performed and revealed a hypocellular and hypovascular dense collagenous tissue covered by squamous epithelium exhibiting acanthosis and elongated rete ridges. The diagnosis was HGF. The treatment instituted was an association of gingivectomy with a rigorous program of oral hygiene and follow-up. Herein, we describe a rare non-syndromic case of generalized HGF, including clinical and microscopical features, as well as highlighting the importance of correct diagnosis of this genetic condition.

Keywords

Gingiva, Gingivectomy, Fibromatosis, Gingival, Dentition, Permanent

References

Gonçalves CF, Mundim AP, Martins RFS, Gagliardi RM, Santos PSS, Toledo OA. Hereditary gingival fibromatosis: a case report with seven-year follow-up.

Acta Stomatol Croat. 2018;52(3):254-8. [https://doi.org/10.15644/asc52/3/9]. [PMID:30510301]

Coletta RD, Graner E. Hereditary gingival fibromatosis: a systematic review.

J Periodontol. 2006;77(5):753-64. [https://doi.org/10.1902/jop.2006.050379]. [PMID:16671866]

Tandon S, Sharma M, Gandhi M, Vijay A. Nonsyndromic gingival fibromatosis: a rare case report.

Int J Clin Pediatr Dent. 2018;11(3):250-3. [https://doi.org/10.5005/jp-journals-10005-1521]. [PMID:30131651]

Brierley DJ, Crane H, Hunter KD. Lumps and bumps of the gingiva: a pathological miscellany.

Head Neck Pathol. 2019;13(1):103-13. [https://doi.org/10.1007/s12105-019-01000-w]. [PMID:30693455]

Manoj M, Garg R, Babu K. Unusual presentation of familial gingival fibromatosis among male siblings.

J Indian Soc Periodontol. 2017;21(2):152-5. [https://doi.org/10.4103/jisp.jisp_207_16]. [PMID:29398861]

Aboujaoude S, Cassia A, Moukarzel C. Diode laser versus scalpel in the treatment of hereditary gingival fibromatosis in a 6-year old boy.

Clin Pract. 2016;6(4):895. [https://doi.org/10.4081/cp.2016.895]. [PMID:27994842]

Almiñana-Pastor PJ, Buitrago-Vera PJ, Alpiste-Illueca FM, Catalá-Pizarro M. Hereditary gingival fibromatosis: characteristics and treatment approach.

J Clin Exp Dent. 2017;9(4):e599-602. [https://doi.org/10.4317/jced.53644]. [PMID:28469831]

Cunha JLS, Santana AVB, Santana LAM, et al. Regional odontodysplasia affecting the maxilla.

Head Neck Pathol. 2019;2019:1-11. [PMID:30900210]

Chapple ILC, Mealey BL, Van Dyke TE, et al. Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Periodontol. 2018;89(Suppl 1):S74-84. [https://doi.org/10.1002/JPER.17-0719]. [PMID:29926944]

Sandhu SP, Kakar V, Gogia G, Narula SC. Unilateral gingival fibromatosis with localized aggressive periodontitis (involving first molars): an unusual case report.

J Indian Soc Periodontol. 2009;13(2):109-13. [https://doi.org/10.4103/0972-124X.55834]. [PMID:20407661]

Ramakrishnan T, Kaur M. Multispeciality approach in the management of patient with hereditary gingival fibromatosis: 1-year followup: a case report.

Int J Dent. 2010;2010:575979. [https://doi.org/10.1155/2010/575979]. [PMID:21234408]

Bansal A, Sowmya K, Narang S, Sehgal N. Treatment and two-year follow-up of a patient with hereditary gingival fibromatosis.

J Indian Soc Periodontol. 2011;15(4):406-9. [https://doi.org/10.4103/0972-124X.92581]. [PMID:22368369]

Dhadse PV, Yeltiwar RK, Pandilwar PK, Gosavi SR. Hereditary gingival fibromatosis.

J Indian Soc Periodontol. 2012;16(4):606-9. [https://doi.org/10.4103/0972-124X.106930]. [PMID:23492855]

Goyal L, Bey A, Gupta ND, Varshney A. Diagnosis and management of nonsyndromic hereditary gingival fibromatosis in a 13 year old girl: report of a rare case.

Contemp Clin Dent. 2012;3(6, Suppl 2):S210-3. [https://doi.org/10.4103/0976-237X.101097]. [PMID:23230366]

Goyal D, Ray A, Sharma S, Shah G. Familial gingival fibromatosis: A rare case report.

Contemp Clin Dent. 2012;3(5, Suppl 1):S63-6. [https://doi.org/10.4103/0976-237X.95108]. [PMID:22629070]

Aghili H, Goldani Moghadam M. Hereditary gingival fibromatosis: a review and a report of a rare case.

Case Rep Dent. 2013;2013:930972. [https://doi.org/10.1155/2013/930972]. [PMID:23533834]

Majumder P, Nair V, Mukherjee M, Ghosh S, Dey SK. The autosomal recessive inheritance of hereditary gingival fibromatosis.

Case Rep Dent. 2013;2013:432864. [https://doi.org/10.1155/2013/432864]. [PMID:24416600]

Peeran SW, Ramalingam K, Peeran SA, Mugrabi MH, Abdulla KA. Hereditary nonsyndromic gingival fibromatosis: report of family case series.

Case Rep Dent. 2013;2013:835989. [https://doi.org/10.1155/2013/835989]. [PMID:24191204]

Chaurasia A. Hereditary gingival fibromatosis.

Natl J Maxillofac Surg. 2014;5(1):42-6. [https://doi.org/10.4103/0975-5950.140171]. [PMID:25298717]

Tripathi AK, Upadhaya V, Kumar V, Saimbi CS. Hereditary gingival fibromatosis and its management: 2-year follow-up.

Contemp Clin Dent. 2014;5(4):569-71. [https://doi.org/10.4103/0976-237X.142835]. [PMID:25395783]

Pego SP, Coletta RD, Mendes DC, et al. Hereditary gingival fibromatosis: clinical and ultrastructural features of a new family.

Med Oral Patol Oral Cir Bucal. 2015;20(2):e150-5. [https://doi.org/10.4317/medoral.20170]. [PMID:25475776]

Tripathi AK, Dete G, Saimbi CS, Kumar V. Management of hereditary gingival fibromatosis: A 2 years follow-up case report.

J Indian Soc Periodontol. 2015;19(3):342-4. [https://doi.org/10.4103/0972-124X.148643]. [PMID:26229281]

Gawron K, Łazarz-Bartyzel K, Fertala A, Plakwicz P, Potempa J, Chomyszyn-Gajewska M. Gingival Fibromatosis with Significant De Novo Formation of Fibrotic Tissue and a High Rate of Recurrence.

Am J Case Rep. 2016;17:655-9. [https://doi.org/10.12659/AJCR.899997]. [PMID:27609299]

Lobo TM, Pol DG, Pol SD. Idiopathic gingival fibromatosis with asymmetrical presentation and electrosurgical management.

J Indian Soc Periodontol. 2016;20(1):98-102. [https://doi.org/10.4103/0972-124X.170831]. [PMID:27041849]

Beaumont J, Chesterman J, Kellett M, Durey K. Gingival overgrowth: part 1: aetiology and clinical diagnosis.

Br Dent J. 2017;222(2):85-91. [https://doi.org/10.1038/sj.bdj.2017.71]. [PMID:28127024]

Suassuna TM, Almeida AB, Landim FS, Medeiros MF, Perez DEC. Extensive idiopathic gingival fibromatosis: a case report.

Rev Cir Traumatol Buco-Maxilo-Fac. 2016;16(4):40-44.

Bökenkamp A, Bohnhorst B, Beier C, Albers N, Offner G, Brodehl J. Nifedipine aggravates cyclosporine A-induced gingival hyperplasia.

Pediatr Nephrol. 1994;8(2):181-5. [https://doi.org/10.1007/BF00865474]. [PMID:8018496]

Bekisz O, Darimont F, Rompen EH. Diffuse but unilateral gingival enlargement associated with von Recklinghausen neurofibromatosis: a case report.

J Clin Periodontol. 2000;27(5):361-5. [https://doi.org/10.1034/j.1600-051x.2000.027005361.x]. [PMID:10847541]

Korol UB, Schoor R, Nanda V, Almas K, Phelan JA. Gingival enlargement as a manifestation of tuberous sclerosis: case report and periodontal management.

J Periodontol. 2008;79(4):759-63. [https://doi.org/10.1902/jop.2008.070407]. [PMID:18380572]

Jagtap RR, Deshpande GS. Gingival enlargement in partial hemifacial hyperplasia.

J Indian Soc Periodontol. 2014;18(6):772-5. [PMID:25624636]

Demirer S, Özdemir H, Şencanc M, Marakoğlud I. Gingival hyperplasia as an early diagnostic oral manifestation in acute monocytic leukemia: a case report.

Eur J Dent. 2007;1(2):111-4. [https://doi.org/10.1055/s-0039-1698323]. [PMID:19212486]

Chowdhri K, Tandon S, Lamba AK, Faraz F. Leukemic gingival enlargement: a case report and review of literature.

J Oral Maxillofac Pathol. 2018;22(4, Suppl 1):S77-81. [https://doi.org/10.4103/jomfp.JOMFP_205_17]. [PMID:29491612]

Livada R, Shiloah J. Calcium channel blocker-induced gingival enlargement.

J Hum Hypertens. 2014;28(1):10-4. [https://doi.org/10.1038/jhh.2013.47]. [PMID:23739159]

Yadav VS, Tewari S, Sharma RK, Chakraborty S. An unusual case of idiopathic gingival fibromatosis.

Contemp Clin Dent. 2013;4(1):102-4. [https://doi.org/10.4103/0976-237X.111623]. [PMID:23853465]

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


Publication date:
01/21/2020

5e26eaad0e8825ee330c3b23 autopsy Articles
Links & Downloads

Autops Case Rep

Share this page
Page Sections