Ameloblastoma is an uncommon and locally aggressive, benign, odontogenic tumor, with local recurrence when not adequately excised. A rare variant of this neoplasm with the benign features but accompanied with metastases has been described. This rare variant is malignant ameloblastoma and is known to have a poor prognosis. We present the case of a young woman who had recurrent mandibular tumors, which were resected twice and histologically reported as ameloblastoma. Four years later, she presented with pulmonary metastasis and atelectasis. A review of the literature on this very rare neoplasm was also performed.
JayarajG, SherlinHJ, RamaniP, et al. Metastasizing ameloblastoma - a perennial pathological enigma? Report of a case and review of literature. J Craniomaxillofac Surg. 2014;42(6):772-9. [https://doi.org/10.1016/j.jcms.2013.11.009]. [PMID:24342734]
AjagbeHA, DaramolaJO. Ameloblastoma: a survey of 199 cases in the University of College Hospital, Ibadan, Nigeria. J Natl Med Assoc. 1987;79(3):324-7. [PMID:3573061]
LadeindeAL, OgunleweMO, BamgboseBO, et al. Ameloblastoma: analysis of 207 cases in a Nigerian teaching hospital. Quintessence Int. 2006;37(1):69-74. [PMID:16429706]
KodatiS, MajumdarS, UppalaD, NamanaM. Ameloblastic carcinoma: a report of three cases. J Clin Diagn Res. 2016;10(10):23-5. [PMID:27891485]
Van DamSD, UnniKK, KellerEE. Metastasizing (malignant) ameloblastoma: review of a unique histopathologic entity and report of Mayo Clinic experience. J Oral Maxillofac Surg. 2010;68(12):2962-74. [https://doi.org/10.1016/j.joms.2010.05.084]. [PMID:20970910]
GeorgakasI, LazaridouM, DimitrakopoulosI, et al. Pulmonary metastasis in a 65-year-old man with mandibular ameloblastoma: a case report and review of the literature. J Oral Maxillofac Surg. 2012;70(5):1109-13. [https://doi.org/10.1016/j.joms.2011.04.011]. [PMID:21835527]
BrownNA, BetzBL. Ameloblastoma: a review of recent molecular pathogenetic discoveries. Biomark Cancer. 2015;7(Suppl 2):19-24. [PMID:26483612]