Sinus histiocytosis with massive lymphadenopathy, generally known by the name of Rosai-Dorfman disease is a rare benign condition principally affecting cervical lymph nodes. Concurrent extra-nodal disease frequently occurs, however, solitary extra-nodal disease involving the mandible is exceedingly rare with less than five reported cases in the English literature. We describe a case of primary involvement of the mandible in a 27-year-old female, and discuss the differential diagnosis of this disease with other histiocytic lesions.
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Histiocytosis Association. Rosai-Dorfman disease: diagnosis and treatment [Internet]. New Jersey: Histiocytosis Association Inc; 2018 [cited 2018 Feb 17]. Available from: https://www.histio.org/page.aspx?pid=401#.WoiD5qjwbIU