Simultaneous calcified fibrous pseudotumor (CFT) and Castleman disease (CD) is an extremely rare association. CD is an uncommon lymphoproliferative disease that can arise in various sites of the body, while CFT is a rare type of benign fibrous lesion that frequently affects children and young adults, occurring as solitary or multiple lesions throughout the human body. Both entities are rare and exhibit typical and diverse histomorphological features. We report the case of a 15-year-old female patient, who, at the age of 13 had a biopsy performed at an external medical center; however, after 4 months the lesion had regrown. This lesion was removed with a surgical operation; however, it regrew 2 years later and was removed a third time. The results of the latter two biopsies were the same: CFT accompanying CD. The histologic examination of the excised lymph node and the surrounding tissue showed hyalinized fibrous tissue containing dystrophic and psammomatous calcification. In this case, the hyaline vascular type of CD was found to be intertwined with a CFT, which hampered the differentiation of whether both entities emerged within the lymph node or if the CFT developed from the soft tissue and then involved the lymph node. Future studies involving larger case series will provide a more precise insight, which should serve to resolve the current uncertainty.
Keywords
Castleman Disease, Pathology, Tumor
References
RosenthalNS, Abdul-KarimFW. Childhood fibrous tumor with psammoma bodies. Clinicopathologic features in two cases. Arch Pathol Lab Med. 1988;112(8):798-800. [PMID:3395217]
MaH, JiangM, XiaoW. A rare stroma-rich variant of hyaline-vascular Castleman’s disease associated with calcifying fibrous pseudotumor. Int J Clin Exp Pathol. 2015;8(3):3362-4. [PMID:26045869]
GündüzE. Nadir bir lenfoproliferatif hastalık: Castleman hastalığı. Osmangazi J Med. 2016;38:6-16.
BüyükbeşeMA, ÖzdemirS, HilalA, et al. Hepatosplenomegali ile başvuran bir hbsag taşıyıcısında castleman hastalığı. Cerrahpaşa Tıp Dergisi. 1999;30(3):228-32.
GamsızkanM, YıldırımC, DaşK, GünhanÖ. Calcifying fibrous tumor: A case report/kalsifiye fibröz tümör: Olgu sunumu. Turkish J Pathol. 2015;31(2):141-4.
DanonAD, KrishnanJ, FrizzeraG. Morpho-immunophenotypic diversity of Castleman’s disease, hyaline-vascular type: with emphasis on a stroma-rich variant and a new pathogenetic hypothesis. Virchows Arch A Pathol Anat Histopathol. 1993;423(5):369-82. [https://doi.org/10.1007/BF01607150]. [PMID:8116226]
DargentJ-L, DelplaceJ, RoufosseC, LagetJP, LespagnardL. Development of a calcifying fibrous pseudotumour within a lesion of Castleman disease, hyaline-vascular subtype. J Clin Pathol. 1999;52(7):547-9. [https://doi.org/10.1136/jcp.52.7.547]. [PMID:10605414]
ValladolidG, WeisenbergE, SundaresanR, MakerAV. Calcifying fibrous tumor of the small intestine associated with Castleman-like lymphadenopathy. J Gastrointest Surg. 2014;18(6):1205-8. [https://doi.org/10.1007/s11605-014-2458-8]. [PMID:24452381]
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