Pancreatic metastases are rare; they account for only 2% of all pancreatic malignancies and usually occur when associated with a disseminated metastatic disease. Solitary pancreatic metastases are even less frequent, and there are few reports regarding surgical resection. We report the case of a 77-year-old female patient diagnosed with a single cephalo-pancreatic metastasis of renal cell carcinoma, 16 years after a total nephrectomy. The patient underwent successful pancreaticoduodenectomy, and the diagnosis was confirmed. A subsequent positron emission tomography (PET) scan showed disease relapse, and tyrosine kinase inhibitor treatment with sunitinib was initiated. After 1 year and 4 months, the PET-computed tomography scan showed a complete radiologic response.
YoshinagaS, SuzukiH, OdaI, SaitoY. Role of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for diagnosis of solid pancreatic masses. Dig Endosc. 2011;23(Suppl. 1):29-33. [https://doi.org/10.1111/j.1443-1661.2011.01112.x]. [PMID:21535197]
RitchieAW, ChisholmGD. The natural history of renal carcinoma. Semin Oncol. 1983;10(4):390-400. [PMID:6665566]
TanisPJ, van der GaagNA, BuschOR, van GulikTM, GoumaDJ. Systematic review of pancreatic surgery for metastatic renal cell carcinoma. Br J Surg. 2009;96(6):579-92. [https://doi.org/10.1002/bjs.6606]. [PMID:19434703]
ZerbiA, OrtolanoE, BalzanoG, BorriA, BeneduceAA, Di CarloV. Pancreatic metastasis from renal cell carcinoma: which patients benefit from surgical resection?Ann Surg Oncol. 2008;15(4):1161-8. [https://doi.org/10.1245/s10434-007-9782-0]. [PMID:18196343]
RamanSP, HrubanRH, CameronJL, WolfgangCL, FishmanEK. Pancreatic imaging mimics: Part 2, pancreatic neuroendocrine tumors and their mimics. AJR Am J Roentgenol. 2012;199(2):309-18. [https://doi.org/10.2214/AJR.12.8627]. [PMID:22826391]
ItoiT, TsuchiyaT, ItokawaF, et al. Histological diagnosis by EUS-guided fine-needle aspiration biopsy in pancreatic solid masses without on-site cytopathologist: A single-center experience. Dig Endosc. 2011;23(Suppl. 1):34-8. [https://doi.org/10.1111/j.1443-1661.2011.01142.x]. [PMID:21535198]
EscudierB, PortaC, SchmidingerM, et al. Renal cell carcinoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2016;27(Suppl. 5):v58-68. [https://doi.org/10.1093/annonc/mdw328]. [PMID:27664262]
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