Autopsy and Case Reports
https://app.periodikos.com.br/journal/autopsy/article/doi/10.4322/acr.2015.003
Autopsy and Case Reports
Article / Clinical Case Report

An interesting finding in the uterine cervix: calcified eggs

Alexia Toller; Ana Carolina Scopin; Vanessa Apfel; Karla Calaça Kabbach Prigenzi; Fernanda Kesselring Tso; Gustavo Rubino de Azevedo Focchi; Neila Speck; Julisa Ribalta

http://dx.doi.org/10.4322/acr.2015.003 Autops Case Rep, vol.5, n2, p.41-44, 2015
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Abstract

Schistosoma hematobium infection is an endemic parasitic disease in Africa, which is frequently associated with urinary schistosomiasis. The parasite infection causes epithelial changes and disruption, facilitating the infection by the human papilloma virus and human immunodeficiency virus (HIV).

The authors report the case of a 44-year-old African HIV-positive woman who presented an abnormal routine Pap smear. Colposcopy examination revealed dense acetowhite micropapillary epithelium covering the ectocervix, iodine-negative, an erosion area in endocervical canal, and atypical vessels. Histologic examination of the surgical specimens showed numerous calcified schistosome eggs (probably S. hematobium) and a high-grade cervical intraepithelial neoplasia.

The relation between S. hematobium infection and bladder cancer is well known; however, this relationship with cervical cancer remains controversial. The symptoms of schistosomiasis of the female genital tract are rather non-specific, and are often misdiagnosed with other pelvic diseases. The familiarity of health professionals with schistosomiasis of the female genital tract is less than expected, even in endemic regions. Therefore, great awareness of this differential diagnosis in routine gynecological practice is of paramount importance.
 

Keywords

Schistosoma hematobium, Genital Diseases, Female, Schistosomiasis hematobia, HIV

References

Centers for Disease Control and Prevention (CDC). Parasites – Schistosomiasis [Internet]. Atlanta [cited 2014 Feb]. Available from: http://www.cdc.gov/parasites/schistosomiasis /epi.html

World Health Organization (WHO). Schistosomiasis [Internet]. Geneva; 2014. Fact Sheet, 115. [2015 May]. Available from: http://www.who.int/mediacentre/factsheets/fs115/en/

Kjetland EF, Leutscher PD, Ndhlovu PD. A review of female genital schistosomiasis. Trends Parasitol. 2012;28(2):58-65. [https://doi.org/10.1016/j.pt.2011.10.008]. [PMID:22245065]

Poggensee G, Feldmeier H, Krantz I. Schistosomiasis of the female genital tract: public health aspects. Parasitol Today. 1999;15(9):378-81. [https://doi.org/10.1016/S0169-4758(99)01497-0]. [PMID:10461167]

Poggensee G, Feldmeier H. Female genital schistosomiasis: facts and hypotheses. Acta Trop. 2001;79(3):193-210. [https://doi.org/10.1016/S0001-706X(01)00086-9]. [PMID:11412803]

van Bogaert LJ. Biopsy-diagnosed female genital schistosomiasis in rural Limpopo, South Africa. Int J Gynaecol Obstet. 2011;115(1):75-6. [https://doi.org/10.1016/j.ijgo.2011.05.010]. [PMID:21767837]

Swai B, Poggensee G, Mtweve S, Krantz I. Female genital schistosomiasis as an evidence of a neglected cause for reproductive ill-health: a retrospective histopathological study from Tanzania. BMC Infect Dis. 2006;6(1):134. [https://doi.org/10.1186/1471-2334-6-134]. [PMID:16928276]

Kjetland EF, Norseth HM, Taylor M, et al. Classification of the lesions observed in female genital schistosomiasis. Int J Gynaecol Obstet. 2014;127(3):227-8. [https://doi.org/10.1016/j.ijgo.2014.07.014]. [PMID:25179171]

Kleppa E, Klinge KF, Galaphaththi-Arachchige HN, et al. Schistosoma haematobium infection and CD4+ T-cell levels: a cross-sectional study of young South African women. PLoS One. 2015;10(3):e0119326. [https://doi.org/10.1371/journal.pone.0119326]. [PMID:25768005]

Jourdan PM, Roald B, Poggensee G, Gundersen SG, Kjetland EF. Increased vascularity in cervicovaginal mucosa with association with Schistosoma hematobium infection. PLoS Negl Trop Dis. 2011;5(6):e1170. [https://doi.org/10.1371/journal.pntd.0001170]. [PMID:21666790]

Helling-Giese G, Sjaastad A, Poggensee G, et al. Female genital schistosomiasis (FGS): relationship between gynecological and histopathological findings. Acta Trop. 1996;62(4):257-67. [https://doi.org/10.1016/S0001-706X(96)00027-7]. [PMID:9028410]

Kallestrup P, Zinyama R, Gomo E, et al. Schistosomiasis and HIV-1 infection in rural Zimbabwe: effect of treatment of schistosomiasis on CD4 cell count and plasma HIV-1 RNA load. J Infect Dis. 2005;192(11):1956-61. [https://doi.org/10.1086/497696]. [PMID:16267767]


 

Publication date:
01/12/2016

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