Autopsy and Case Reports
https://app.periodikos.com.br/journal/autopsy/article/doi/10.4322/acr.2014.008
Autopsy and Case Reports
Article / Clinical Case Report

Medullary carcinoma of the thyroid metastatic to the breast: a case report and literature review

Sebastião Nunes Martins Filho; Marcelo Abrantes Giannotti; Sheila Aparecida Coelho Siqueira

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Abstract

Breast malignancies, apart from skin cancer, are the leading cause of cancer from cancer among the female population. Unlike the high prevalence of primary mammary malignancies, metastases to the breast are uncommon, and account for only 0.2-2.7% of all malignancies affecting this organ. We report the case of a 35-year-old woman who sought medical care because of a breast lump. A mammogram suggested a breast tumor, which was biopsied. The histopathological workup resulted in the diagnosis of a metastasis from a medullary thyroid cancer. The authors review the most useful clinical, radiological, histological, and immunohistochemical features concerning extramammary malignancy to the breast.
 

Keywords

Breast Neoplasms, Carcinoma, Medullary, Neoplasm Metastasis

References

Gavilán I, Astorga R, Sasián Set al. Medullary carcinoma of the thyroid gland. Prognostic factors. Rev Clin Esp. 1996;196:92-8. PMid: [PMID:8685495].

Pelizzo MR, Boschin IM, Bernante Pet al. Natural history, diagnosis, treatment and outcome of medullary thyroid cancer: 37 years experience on 157 patients. Eur J Surg Oncol. 2007;33:493-7. Epub 2006 Nov 27. PMid: [PMID:17125960]. http://dx.doi.org/ [https://doi.org/10.1016/j.ejso.2006.10.021]

Vaughan A, Dietz JR, Moley JFet al. Metastatic disease to the breast: the Washington University experience. World J Surg Oncol. 2007;5:74. PMid: [PMID:17615059] PMCid:PMC [PMID:17615059]. http://dx.doi.org/ [https://doi.org/10.1186/1477-7819-5-74]

Nofech-Mozes S, Mackenzie R, Kahn HJ, Ehrlich L, Raphael SJ. Breast metastasis by medullary thyroid carcinoma detected by fdg positron emission tomography. Ann Diagn Pathol. 2008;12:67-71. PMid: [PMID:18164420]. http://dx.doi.org/ [https://doi.org/10.1016/j.anndiagpath.2006.08.004]

Rodríguez-Gil Y, Pérez-Barrios A, Alberti-Masgrau Net al. Fine Needle aspiration cytology diagnosis of metastatic non haematological neoplasms of the breast: a series of seven cases. Diagn Cytopathol. 2012;40:297-304. [https://doi.org/10.1002/dc.21559] http://dx.doi.org/ [https://doi.org/10.1002/dc.21559]

Instituto Nacional do Câncer (BR). Estimativa 2014: incidência de câncer no Brasil. Rio de Janeiro; 2014 [cited 2014 January 15]. Available from: http://www2.inca.gov.br/wps/wcm/connect/0129ba0041fbbc01aa4fee936e134226/Apresentacao+Estimativa+2014_final+corrigido+tireoide.pdf?MOD=AJPERES&CACHEID=0129ba0041fbbc01aa4fee936e134226" xmlns:xlink="http://www2.inca.gov.br/wps/wcm/connect/0129ba0041fbbc01aa4fee936e134226/Apresentacao+Estimativa+2014_final+corrigido+tireoide.pdf?MOD=AJPERES&CACHEID=0129ba0041fbbc01aa4fee936e134226" target="_blank" title="http://www.w3.org/1999/xlink">http://www2.inca.gov.br/wps/wcm/connect/0129ba0041fbbc01aa4fee936e134226/Apresentacao+Estimativa+2014_final+corrigido+tireoide.pdf?MOD=AJPERES&CACHEID=0129ba0041fbbc01aa4fee936e134226">http://www.w3.org/1999/xlink">http://www2.inca.gov.br/wps/wcm/connect/0129ba0041fbbc01aa4fee936e134226/Apresentacao+Estimativa+2014_final+corrigido+tireoide.pdf?MOD=AJPERES&CACHEID=0129ba0041fbbc01aa4fee936e134226

Lee AH. The histological diagnosis of metastases to the breast from extramammary malignancies. J Clin Pathol. 2007;60:1333-41. PMid: [PMID:18042689] PMCid:PMC [PMID:18042689]. http://dx.doi.org/ [https://doi.org/10.1136/jcp.2006.046078]

Lee SK, Kim WW, Kim SHet al. Characteristics of metastasis in the breast from extramammary malignancies. J Surg Oncol. 2010;101:137-40. PMid: [PMID:20082359]. http://dx.doi.org/ [https://doi.org/10.1002/jso.21453]

Ribeiro-Silva A, Mendes CF, Costa IS, De Moura HB, Tiezzi DG, Andrade JM. Metastases to the breast from extramammary malignancies: a clinicopathologic study of 12 cases. Pol J Pathol. 2006;57:161-5. PMid: [PMID:17219743].

Smymiotis V, Theodosopoulos T, Marinis Aet al. Metastatic disease in the breast from nonmammary neoplasms. Eur J Gynaecol Oncol. 2005;26:547-50. PMid: [PMID:16285577].

Chaignaud B, Hall TJ, Powers C, Subramony C, Scott-Conner CE. Diagnosis and natural history of extramammary tumors metastatic to the breast. J Am Coll Surg. 1994;179:49-53. PMid: [PMID:8019724].

Sandison A T. Metastatic tumours in the breast. Br J Surg. 1959;47:548. PMid: [PMID:14441414]. http://dx.doi.org/ [https://doi.org/10.1002/bjs.18004720111]

Duncan VE, Reddy VVB, Jhala NC, Chhieng DC, Jhala DN. Non-Hodgkin’s lymphoma of the breast: a review of 18 primary and secondary cases. Ann Diagn Pathol. 2006;10:144-8. PMid: [PMID:16730308]. http://dx.doi.org/ [https://doi.org/10.1016/j.anndiagpath.2005.09.018]

Domchek S M, Hecht J L, Fleming MD, Pinkus GS, Canellos GP. Lymphomas of the breast: primary and secondary involvement. Cancer. 2002;94:6-13. PMid: [PMID:11815954]. http://dx.doi.org/ [https://doi.org/10.1002/cncr.10163]

Sanguinetti A, Puma F, Lucchini Ret al. Breast metastasis from a pulmonary adenocarcinoma: Case report and review of the literature. Oncol Lett. 2013;5:328-32. PMid: [PMID:23255943] PMCid:PMC [PMID:23255943].

Dursun P, Yanik FB, Kuscu E, Gultekin M, Ayhan A. Bilateral breast metastasis of ovarian carcinoma. Eur J Gynaecol Oncol. 2009;30:9-12. PMid: [PMID:19317248].

Yeh CN, Lin CH, Chen MF. Clinical and ultrasonographic characteristics of breast metastases from extramammary malignancies. Am Surg. 2004;70:287-90. PMid: [PMID:15098776].

Correa Geyer F, Reis-Filho JS. Microarray-based gene expression profiling as a clinical tool for breast cancer management: are we there yet? Int J Surg Pathol. 2009;17:285-302. PMid: [PMID:19103611]. http://dx.doi.org/ [https://doi.org/10.1177/1066896908328577]

Schnitt SJ. Will molecular classification replace traditional breast pathology? Int J Surg Pathol. 2010;18(3 Suppl):162S-6S. PMid: [PMID:20484283]. http://dx.doi.org/ [https://doi.org/10.1177/1066896910370771]

Aleskandarany MA, Green AR, Benhasouna AAet al. Prognostic value of proliferation assay in the luminal, HER2-positive, and triple-negative biologic classes of breast cancer. Breast Cancer Res. 2012;14:R3. PMid: [PMID:22225836] PMCid:PMC [PMID:22225836]. http://dx.doi.org/ [https://doi.org/10.1186/bcr3084]

Sentani K, Oue N, Noguchi T, Sakamoto N, Matsusaki K, Yasui W. Immunostaining of gastric cancer with neuroendocrine differentiation: Reg IV-positive neuroendocrine cells are associated with gastrin, serotonin, pancreatic polypeptide and somatostatin. Pathol Int. 2010;60:291-7. PMid: [PMID:20403031]. http://dx.doi.org/ [https://doi.org/10.1111/j.1440-1827.2010.02519.x]

Oba H, Nishida K, Takeuchi Set al. Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia with a central and peripheral carcinoid and multiple tumorlets: a case report emphasizing the role of neuropeptide hormones and human gonadotropin-alpha. Endocr Pathol. 2013;24:220-8. PMid: [PMID:24006219]. http://dx.doi.org/ [https://doi.org/10.1007/s12022-013-9265-8]


 


Publication date:
01/13/2016

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