Polímeros: Ciência e Tecnologia
http://app.periodikos.com.br/journal/polimeros/article/doi/10.1590/S0104-14282005000200006
Polímeros: Ciência e Tecnologia
Scientific & Technical Article

Interaction between Cholesterol and Chitosan in Langmuir Monolayers

Oliveira Junior, Osvaldo N.; Santos Junior, David S. dos; Pavinatto, Felippe J.

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Abstract

Chitosan incorporated in the aqueous subphase is found to affect the Langmuir monolayers of cholesterol, causing the surface pressure and the surface potential isotherms to become more expanded. The mean molecular area per cholesterol molecule in the condensed monolayer increases from 53 Å2 in the absence of chitosan to 61 Å2 for a concentration of 0.100 mg/mL of chitosan in the subphase. If additional chitosan is incorporated in the subphase, no change is noted, which points to saturation in the effects from chitosan. The interaction between chitosan and cholesterol probably occurs via hydrogen bonding. The monolayer expansion is also manifested in the monolayer morphology, as indicated by Brewster angle microscopy measurements, where larger cholesterol domains are visualized when chitosan is present in the subphase.

Keywords

Cholesterol, chitosan, Langmuir monolayers

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